Handling Precautions: closed operation, full ventilation. The operator must go through specialized training, strict adherence to rules. Proposed operators wear self-absorption filter respirators (half-mask), wearing chemical protective safety glasses, lactic acid powder overalls, wearing rubber gloves. Keep away from fire, heat, workplace smoking. Use explosion-proof ventilation systems and equipment. Prevent vapor leakage into the workplace air. Avoid contact with oxidizing agents, acids, alkalis contacts. Handling of light when light unloading, packaging and containers to prevent damage. Equipped with the appropriate variety and quantity of fire equipment and emergency equipment leakage. Empty containers may be harmful residues.
Storage Precautions: Store in a cool, ventilated warehouse. Keep away from fire and heat. Keep container tightly closed. Should oxidants, acids, bases stored separately and Lactic acid reservoir. Explosion-proof lighting, ventilation facilities. Prohibit the use of easy to produce sparks of mechanical equipment and tools. Storage areas should be equipped with spill response equipment and materials suitable host.
2013年7月31日星期三
Some measures lactate ethanol
Skin contact: Remove contaminated clothing, use soap and water thoroughly washed skin.
Eye contact: immediately filed eyelid, with a large number of mobile water or saline thoroughly washed at least 15 minutes. Doctor.
Inhalation: rapidly from magnessium lactate fresh air. Keep the airway patency. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Doctor.
Ingestion: drink plenty of water, induce vomiting. Doctor.
Hazardous combustion products: Calcium lactate, carbon dioxide.
Fire fighting methods: water cooling containers, if possible to move containers from the scene empty Department.
Extinguishing Media: Alcohol-resistant foam, water spray, dry powder, carbon dioxide, sand.
Eye contact: immediately filed eyelid, with a large number of mobile water or saline thoroughly washed at least 15 minutes. Doctor.
Inhalation: rapidly from magnessium lactate fresh air. Keep the airway patency. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Doctor.
Ingestion: drink plenty of water, induce vomiting. Doctor.
Hazardous combustion products: Calcium lactate, carbon dioxide.
Fire fighting methods: water cooling containers, if possible to move containers from the scene empty Department.
Extinguishing Media: Alcohol-resistant foam, water spray, dry powder, carbon dioxide, sand.
Lactic acid and ethanol
1.Lactic acid and ethanol in the presence of sulfuric acid esterification.
2. To acetaldehyde and ferrous lactate as raw materials, the reaction of ethylene cyanohydrin, and then with ethanol in the presence of inorganic acid esterification.
3, metal halide catalyzed method. Instead of concentrated sulfuric acid with a metal halide Synthesis of ethyl lactate, the yield of 65% -71%. [5]
4, rare earth compounds catalyzed. Ethanol 0.22-0.33mol, lactic 0.11mol, and a rare earth compound with 25mL agent (molar ratio of the acid 1:100) was added to the flask, a reflux reaction 2.5-3h, the reaction solution was evaporated to an excess of ethanol with liquid, and The unreacted lactic acid after vacuum distillation, collecting product, yield 74% -79%.
5, sulfuric acid catalysis. Ethyl lactate esterification of lactic acid with an excess of ethanol derived ethyl lactate; also be heated in carbon tetrachloride will flow dehydration 24h, atmospheric distillation recycling excess ethanol and then vacuum distilled products. [5]
6, the solid acid catalysis. NaY zeolite was washed with water, dried, high temperature burning, and then impregnated with a certain concentration of NH4Cl solution was stirred for ion exchange, the NH4Y filtered, washed, dried, 550 ℃ high temperature activation, ie solid acid HY. Then lactic acid, ethanol, benzene, HY added to the reaction flask, HY / lactic acid (mass ratio) = 25/100, acid / ethanol (molar ratio) = 1/3. Refluxing the reaction under 100-160 ℃ 8-10h, the esterification rate of 60% or more. 7, distillation esterification. The 225g80% of lactic acid, 475Ml (380g) 95% ethanol, 100mL of benzene, 2 mL of concentrated sulfuric acid and adding a little water separator distillation apparatus zeolite flask (1000 mL) in. Added to the reaction solution to a boil, steam (ethanol, benzene and water) into the condenser through the distillation column, the water layer was separated and refluxed to the distillation column, column top temperature stabilized at 64.9 ℃. When the aqueous layer was 240g (containing ethanol 119g, water, 99g, benzene, 22g), the basic water separation, the column top temperature was raised to 68 ℃, esterification ends. After cooling, the reaction solution 6g of anhydrous sodium acetate and sulfuric acid by distillation under reduced pressure. First total reflux 1h, and then under vacuum in 2.45Kpa control reflux ratio of not less than 5, a head temperature of 58 ℃, distillation clear colorless ethyl lactate 226g, yield 96%. [5]
8, the lactic acid with an excess of alcohol in the esterification catalyst, after refining.
2. To acetaldehyde and ferrous lactate as raw materials, the reaction of ethylene cyanohydrin, and then with ethanol in the presence of inorganic acid esterification.
3, metal halide catalyzed method. Instead of concentrated sulfuric acid with a metal halide Synthesis of ethyl lactate, the yield of 65% -71%. [5]
4, rare earth compounds catalyzed. Ethanol 0.22-0.33mol, lactic 0.11mol, and a rare earth compound with 25mL agent (molar ratio of the acid 1:100) was added to the flask, a reflux reaction 2.5-3h, the reaction solution was evaporated to an excess of ethanol with liquid, and The unreacted lactic acid after vacuum distillation, collecting product, yield 74% -79%.
5, sulfuric acid catalysis. Ethyl lactate esterification of lactic acid with an excess of ethanol derived ethyl lactate; also be heated in carbon tetrachloride will flow dehydration 24h, atmospheric distillation recycling excess ethanol and then vacuum distilled products. [5]
6, the solid acid catalysis. NaY zeolite was washed with water, dried, high temperature burning, and then impregnated with a certain concentration of NH4Cl solution was stirred for ion exchange, the NH4Y filtered, washed, dried, 550 ℃ high temperature activation, ie solid acid HY. Then lactic acid, ethanol, benzene, HY added to the reaction flask, HY / lactic acid (mass ratio) = 25/100, acid / ethanol (molar ratio) = 1/3. Refluxing the reaction under 100-160 ℃ 8-10h, the esterification rate of 60% or more. 7, distillation esterification. The 225g80% of lactic acid, 475Ml (380g) 95% ethanol, 100mL of benzene, 2 mL of concentrated sulfuric acid and adding a little water separator distillation apparatus zeolite flask (1000 mL) in. Added to the reaction solution to a boil, steam (ethanol, benzene and water) into the condenser through the distillation column, the water layer was separated and refluxed to the distillation column, column top temperature stabilized at 64.9 ℃. When the aqueous layer was 240g (containing ethanol 119g, water, 99g, benzene, 22g), the basic water separation, the column top temperature was raised to 68 ℃, esterification ends. After cooling, the reaction solution 6g of anhydrous sodium acetate and sulfuric acid by distillation under reduced pressure. First total reflux 1h, and then under vacuum in 2.45Kpa control reflux ratio of not less than 5, a head temperature of 58 ℃, distillation clear colorless ethyl lactate 226g, yield 96%. [5]
8, the lactic acid with an excess of alcohol in the esterification catalyst, after refining.
Lactate food
(1) do emulsifiers, humectants, flavor-improving agent, quality-improving agent, antioxidant synergist and pH adjusting agent is widely used in meat and food processing industry, to enhance the flavor, inhibit the growth of pathogenic bacteria in food, extend product shelf life;
(2) sodium Lactic acid a food preservative, flavoring agent, antifreeze, moisturizing agent, has been replaced in the foreign part of sodium benzoate as a preservative used in the food industry. Lactate compared with sodium benzoate, sodium citrate, sodium sorbate, there is not the same match advantage. Especially in meat products has the following significant effects: 1, to extend the shelf life: extended from 30 to 100%, or even longer; 2, inhibit pathogens in food, such as: HT Escherichia coli, lactic acid powder monocytogenes bacteria, bacteria such as Clostridium botulinum bud growth, thereby increasing food security; 3, enhance and maintain the flavor of the meat; 4, as a salt can not only reduce the amount of sodium chloride, and sodium lactate people on low-salt heart disease, high- patient blood pressure, kidney patients, more secure. For example, preparing a balanced fitness potassium and sodium salts.
(2) sodium Lactic acid a food preservative, flavoring agent, antifreeze, moisturizing agent, has been replaced in the foreign part of sodium benzoate as a preservative used in the food industry. Lactate compared with sodium benzoate, sodium citrate, sodium sorbate, there is not the same match advantage. Especially in meat products has the following significant effects: 1, to extend the shelf life: extended from 30 to 100%, or even longer; 2, inhibit pathogens in food, such as: HT Escherichia coli, lactic acid powder monocytogenes bacteria, bacteria such as Clostridium botulinum bud growth, thereby increasing food security; 3, enhance and maintain the flavor of the meat; 4, as a salt can not only reduce the amount of sodium chloride, and sodium lactate people on low-salt heart disease, high- patient blood pressure, kidney patients, more secure. For example, preparing a balanced fitness potassium and sodium salts.
Calcium lactate product features
Product Features: This product is super anhydrous glucose as the main raw material, does not contain sugar, there will be added to the water crystallization phenomena, Calcium lactate first milk, rice flour, rice cereal reconstituted good or warm water before mixing the product together.
Edible method :6-12 months each one (10g) ,1-3 years old every 2 (20 g), 2 to 3 times a day, add 100-150 ml of warm water and buffered lactic acid stirring to drink, but also can be added to reconstituted milk powder, rice flour or rice cereal mixed with food, every time after eating Please sealed to prevent moisture caking.
Edible method :6-12 months each one (10g) ,1-3 years old every 2 (20 g), 2 to 3 times a day, add 100-150 ml of warm water and buffered lactic acid stirring to drink, but also can be added to reconstituted milk powder, rice flour or rice cereal mixed with food, every time after eating Please sealed to prevent moisture caking.
Lactic acid fermentation
1, fermentation
Calcium carbonate as a neutralizing agent for ferrous lactate fermentation broth with lime water and after secondary crystallization, the direct production of lactate. Saccharification fermentation feedstock liquid or paste of rice flour can be used (corn flour) dual enzymatic hydrolysis, the specific reference to lactic acid fermentation.
2, and in France
Lactic acid at 50% of the product was added calcium hydroxide or calcium oxide for neutralization reaction, and then filtered to remove insoluble impurities, and then cooling crystallization, separation, drying products. This process is simple, but the cost is higher. 2C3H6O3 + Ca (OH) 2 → (C3H5O3) 2Ca +2 H2O
3, gelatinization of rice by high pressure, calcium lactate water cooled to 50-53 ℃, access Aspergillus and Lactobacillus delbrueckii, lactic acid fermentation metabolites, calcium phosphate and then added to obtain a crude calcium lactate, and finally purified , or with calcium carbonate and dilute acid solution, and then the solution was evaporated in the system. Refining process is the use of magnesium hydroxide and magnesium hydroxide reacts with calcium, it is the nature of cohesion, so that part of the fermentation broth and protein impurities removed after condensation, and then concentrated in vacuo, crystallization, refining lactate.
Calcium carbonate as a neutralizing agent for ferrous lactate fermentation broth with lime water and after secondary crystallization, the direct production of lactate. Saccharification fermentation feedstock liquid or paste of rice flour can be used (corn flour) dual enzymatic hydrolysis, the specific reference to lactic acid fermentation.
2, and in France
Lactic acid at 50% of the product was added calcium hydroxide or calcium oxide for neutralization reaction, and then filtered to remove insoluble impurities, and then cooling crystallization, separation, drying products. This process is simple, but the cost is higher. 2C3H6O3 + Ca (OH) 2 → (C3H5O3) 2Ca +2 H2O
3, gelatinization of rice by high pressure, calcium lactate water cooled to 50-53 ℃, access Aspergillus and Lactobacillus delbrueckii, lactic acid fermentation metabolites, calcium phosphate and then added to obtain a crude calcium lactate, and finally purified , or with calcium carbonate and dilute acid solution, and then the solution was evaporated in the system. Refining process is the use of magnesium hydroxide and magnesium hydroxide reacts with calcium, it is the nature of cohesion, so that part of the fermentation broth and protein impurities removed after condensation, and then concentrated in vacuo, crystallization, refining lactate.
The body needs a lot of energy
Unlike the general description of the error increase in lactate concentration in itself does not cause acidosis, nor is it cause muscle soreness. Lactic acid in the human body calcium lactate a proton, so there is no acidity. The human body glycolytic pathway analysis show that this process does not lead to acidosis. Strenuous exercise acidosis caused when there is another reason.
Adenosine triphosphate is split in the release of energy is that it releases a proton. These protons are leading causes of acidosis. In the intense aerobic metabolism during exercise can not guarantee the production of adenosine triphosphate, so anaerobic metabolism begins. magnessium lactate can produce a large number of adenosine triphosphate, adenosine triphosphate which the release of a large number of protons in the decomposition, reducing the pH of the tissue, causing acidosis. This is a strong muscle soreness during exercise one of many reasons. It was considered by the strong ion concentration gradient can cause lactic acidosis, but the study of this process is imperfect, it is unclear whether there.
Adenosine triphosphate is split in the release of energy is that it releases a proton. These protons are leading causes of acidosis. In the intense aerobic metabolism during exercise can not guarantee the production of adenosine triphosphate, so anaerobic metabolism begins. magnessium lactate can produce a large number of adenosine triphosphate, adenosine triphosphate which the release of a large number of protons in the decomposition, reducing the pH of the tissue, causing acidosis. This is a strong muscle soreness during exercise one of many reasons. It was considered by the strong ion concentration gradient can cause lactic acidosis, but the study of this process is imperfect, it is unclear whether there.
2013年7月30日星期二
The body of lactic acid after exercise
If the motion is too intense or prolonged, or physical decomposition of lactic acid deficiency in essential vitamins and minerals, the body too late to be processed lactic acid, resulting in the accumulation of calcium lactate. Too much lactic acid will weakly alkaline body fluids acidic, affecting the smooth absorption of nutrients and oxygen to cells, weakening the normal function of cells. Accumulation of potassium lactate in muscle contraction will occur, thus squeezing blood vessels, making poor blood flow, resulting in muscle aches, chills, headache, heavy flu. Accumulation of lactic acid in the initial cause soreness and fatigue, if the long-ignored, resulting in acidic and may cause serious illness.
Some people used to sleep late on holidays to eliminate fatigue, which is invalid. Use chemicals only seek temporary relief, but also have side effects. The correct way is to use the appropriate exercise, especially stretching exercises to relax the muscles, promote blood circulation, select the equalizer light nutrition, especially foods rich in B vitamins, plus the quality of sleep, it will get the best effect.
Some people used to sleep late on holidays to eliminate fatigue, which is invalid. Use chemicals only seek temporary relief, but also have side effects. The correct way is to use the appropriate exercise, especially stretching exercises to relax the muscles, promote blood circulation, select the equalizer light nutrition, especially foods rich in B vitamins, plus the quality of sleep, it will get the best effect.
Lactic acid inhibit microbial growth
Lactic acid inhibit microbial growth. Lactation period of the pig will be infected with by E.Zinc lactate and Salmonella diseases caused by, in the feed to join lactic energy prevent the piggy under the the gastrointestinal tract growth of pathogenic bacteria;ferrous lactate can be used as a preservative and to enhance feed forage, grain and meat by-products processed products of microorganisms stabilizer;in drinking water in poultry and pig adding lactic acid, can effectively inhibit the growth of pathogenic bacteria, animal weight gain speed.
Toxicity protection pure non-toxic. Its salts as long as not too toxic heavy metal salts. Rat oral LD50 is 3730mg/kg.
Toxicity protection pure non-toxic. Its salts as long as not too toxic heavy metal salts. Rat oral LD50 is 3730mg/kg.
Industrial use of lactic acid
1) lactic acid in the fermentation industry for controlling the pH and increasing the purity fermentation;
2) in the cigarette industry can keep the tobacco moisture, removing impurities in tobacco, changing tastes, raising tobacco grades, buffered lactic acid and nicotine in nicotine can reduce harmful ingredients to improve the quality of tobacco;
3) in the textile industry for processing fibers, the fibers can be easily pigmented increase gloss, so soft to the touch;
4) in the paint ink industry as a pH adjusting agent and synthetic agents; in biodegradable plastic fiber industry is new material polylactic acid PLA raw material of choice;
5) The polylactic acid may be used as a starting material, producing a new generation of biodegradable plastics;
6) In the leather industry, Lactic acid can be stripped of lime and calcium in leather, the leather soft and fine, which made of high quality leather;
7) Lactic acid has a unique due to the complexation constants of nickel, nickel plating is often used, which at the same time as the plating bath in the acid buffer and stabilizers. In the microelectronics industry, its unique of high purity and low metal content meet the semiconductor industry for high quality requirements of, it as a safe organic dissolving agent can be used for photosensitive material cleaning;
8) lactic acid as a pH adjusting agent and synthetic agents can be used in various water-based coating of the adhesive system. Such as: electric plot substance of the coating. lactic acid powder low boiling point, very applicable to Yu as a Gao solid coating established safety dissolution systems. Lactic acid product family for the production has good a fluid performance containing high solids coatings provide an opportunity;
9) such as the role of lactic acid has a cleaning detergent for washing cleaning products than traditional organic detergents better performance, so it can be used in many cleaning products. Such as: toilets, bathrooms, coffee machine's cleaning agents. Lactic acid has anti-microbial, and when it and other anti-microbial agents such as ethanol, with the use of a synergistic effect.
2) in the cigarette industry can keep the tobacco moisture, removing impurities in tobacco, changing tastes, raising tobacco grades, buffered lactic acid and nicotine in nicotine can reduce harmful ingredients to improve the quality of tobacco;
3) in the textile industry for processing fibers, the fibers can be easily pigmented increase gloss, so soft to the touch;
4) in the paint ink industry as a pH adjusting agent and synthetic agents; in biodegradable plastic fiber industry is new material polylactic acid PLA raw material of choice;
5) The polylactic acid may be used as a starting material, producing a new generation of biodegradable plastics;
6) In the leather industry, Lactic acid can be stripped of lime and calcium in leather, the leather soft and fine, which made of high quality leather;
7) Lactic acid has a unique due to the complexation constants of nickel, nickel plating is often used, which at the same time as the plating bath in the acid buffer and stabilizers. In the microelectronics industry, its unique of high purity and low metal content meet the semiconductor industry for high quality requirements of, it as a safe organic dissolving agent can be used for photosensitive material cleaning;
8) lactic acid as a pH adjusting agent and synthetic agents can be used in various water-based coating of the adhesive system. Such as: electric plot substance of the coating. lactic acid powder low boiling point, very applicable to Yu as a Gao solid coating established safety dissolution systems. Lactic acid product family for the production has good a fluid performance containing high solids coatings provide an opportunity;
9) such as the role of lactic acid has a cleaning detergent for washing cleaning products than traditional organic detergents better performance, so it can be used in many cleaning products. Such as: toilets, bathrooms, coffee machine's cleaning agents. Lactic acid has anti-microbial, and when it and other anti-microbial agents such as ethanol, with the use of a synergistic effect.
Lactic acid wine
In brewing beer, add the amount of lactic acid to adjust the pH to promote both glycosylated, magnessium lactate to yeast fermentation, improve the quality of beer, but also increase the beer flavor, extend shelf life. In the liquor, sake and wine used to adjust the pH, to prevent bacteria growth, enhance sour and refreshing taste; 5. Buffered Calcium lactate can be used in hard candy, fruit candy and other confectionery products, moderate acidity and sugar conversion rate. Lactic acid powder can be used on all kinds of candy powder, sour agent as a powder.
enzymatic conversion of pyruvate
Lactate dehydrogenase from the highest activity of Lactobacillus DSM20196 confusion cells obtained in Sodium lactate dehydrogenase, a non-optically active pyruvate as substrate D-lactic acid can be obtained.
Industrial production of lactic acid fermentation method and the method is mainly synthesis. Because fermentation process is simple, abundant raw materials, develop and become more mature earlier lactic acid production methods, lactic acid production accounts for about 70 or more, magnessium lactate, only batch or semi-continuous production and quality of domestic non-lactic fermentation to international standards. Chemical method can achieve large-scale continuous production of lactic acid and lactic acid synthesis has also been the U.S. Food and Drug Administration (FDA) approval, but the raw materials are generally toxic, does not meet the requirements of green chemistry. Enzymatic process is complex, and its industrial application needs further study.
Industrial production of lactic acid fermentation method and the method is mainly synthesis. Because fermentation process is simple, abundant raw materials, develop and become more mature earlier lactic acid production methods, lactic acid production accounts for about 70 or more, magnessium lactate, only batch or semi-continuous production and quality of domestic non-lactic fermentation to international standards. Chemical method can achieve large-scale continuous production of lactic acid and lactic acid synthesis has also been the U.S. Food and Drug Administration (FDA) approval, but the raw materials are generally toxic, does not meet the requirements of green chemistry. Enzymatic process is complex, and its industrial application needs further study.
propionic acid chloride enzymatic conversion
The University of Tokyo, Kawasaki and other studies of the use of purified potassium lactate dehalogenase and DL-2-halo acid dehalogenase were acting on the substrate L-2-chloro-propionic acid and DL- 2 - chloro acid, L-lactic acid obtained bittern off or D-lactic acid. L-2-halo acid dehalogenase catalyzed L-2-chloropropionic acid, and zinc lactate dehalogenase catalyzed both L-2-chloropropionic acid, but also the catalytic L-2-chloropropyl generate the corresponding optically active acid, catalytic conversion simultaneous configuration.
2013年7月29日星期一
L calcium lactate and calcium lactate
L lactate white crystalline powder, no odor, solubility than calcium lactate, insoluble in organic solvents, L-lactate as L-lactate, easily soluble in water (solubility than calcium lactate good).
Calcium absorbed by the body in the case of buffered lactic acid can regulate the human microcirculation, no DL-lactate fermentation sour smell, compared with DL-lactate greater use value compared
L-lactate is mainly used for food additives, supplement the body calcium, breads, pastries and other buffering agents, Lactic acid, calcium supplements. Widely used in food, beverage, pharmaceutical and other industries. As a nutrient supplement dosage according to GB14880-94 and GB2760 requirements
Calcium lactate is a good food calcium supplements, calcium absorption better than inorganic. Can be used in infant food, usage is 23 ~ 46g/kg; in grains and their products for 12 ~ 24g/kg;, drinking fluids and milk drinks for 3 ~ 6g/kg. Also leavening agent for bread baking powder and buffers
Calcium absorbed by the body in the case of buffered lactic acid can regulate the human microcirculation, no DL-lactate fermentation sour smell, compared with DL-lactate greater use value compared
L-lactate is mainly used for food additives, supplement the body calcium, breads, pastries and other buffering agents, Lactic acid, calcium supplements. Widely used in food, beverage, pharmaceutical and other industries. As a nutrient supplement dosage according to GB14880-94 and GB2760 requirements
Calcium lactate is a good food calcium supplements, calcium absorption better than inorganic. Can be used in infant food, usage is 23 ~ 46g/kg; in grains and their products for 12 ~ 24g/kg;, drinking fluids and milk drinks for 3 ~ 6g/kg. Also leavening agent for bread baking powder and buffers
Milk calcium and calcium lactate
Milk calcium is extracted from milk natural substances, which contains milk protein separation and purification from a natural physiologically active peptide cPP (casein phosphopeptide), magnessium lactate the body's absorption of calcium. 0-6 years old baby are more suitable. It must be noted, milk calcium itself unsaturated fatty acid content of less and. And calcium, phosphorus ratio properly, which may affect the baby's absorption of calcium.
Calcium lactate is generally made from natural food produced by submerged fermentation of Calcium lactate and calcium consumption through a combination of scientific methods. Since L-lactic acid L-physiological characteristics of the human body generally consistent, and high solubility. Into the human body can be acidified human gastrointestinal tract, improve the utilization of calcium, 0 to 6 years old baby is very suitable.
Calcium lactate is generally made from natural food produced by submerged fermentation of Calcium lactate and calcium consumption through a combination of scientific methods. Since L-lactic acid L-physiological characteristics of the human body generally consistent, and high solubility. Into the human body can be acidified human gastrointestinal tract, improve the utilization of calcium, 0 to 6 years old baby is very suitable.
Lactate determination
To about 0.3g, accurately weighed, add water 100ml, heated to dissolve, let cool, add sodium hydroxide solution 15ml with calcium purpurin indicator about 0.1g, with ethylene diamine Sodium lactate disodium titrant (0.05 mol / L) titration until the solution changes from purple to pure blue. Each 1ml of ethylene diamine tetra acetic acid disodium titrant (0.05mol / L) is equivalent to 15.42mg of C6H10CaO6 · 5H2O. Slightly hazardous for water Do not allow undiluted product or large quantities of it to reach ground water, magnessium lactate or sewage system, without proper governmental permits do not allow material to be released to the environment.
Lactate monitoring
Acidity: take this product 1.0g, add boiling over dissolved in 20ml warm water, let cool, add 2 drops of phenolphthalein indicator solution and sodium hydroxide solution (0.1mol / L) 0.50ml, should be significantly pink.
Chloride: Ethyl lactate product 0.10g, according to inspection, made with standard sodium chloride solution 5.0ml control solution may not be thicker (0.050%).
Sulfate: Take this product 0.40g, according to inspection, made with standard potassium sulfate solution 3.0ml control solution may not be thicker (0.075%).
Barium salt: Take 1.0g, 20ml water to dissolve, is divided into two equal parts, one as a control tube, another plus calcium sulfate solution 1ml, for 15 minutes, compared with the control tube, not thicker.
Molysite: Take this product 0.50g, add water 25ml, dissolved by heating in a water bath, zinc lactate, according to inspection, with the standard iron solution 2.5ml were made using the same method was compared to no deeper (0.005%).
Heavy Metal: Take this product 1.0g, add water 15ml with acetate buffer (pH3.5) 2ml micro heat dissolved, let cool, add water to make into a 25ml, according to inspection, containing heavy metals should not exceed ten millionths.
Arsenic: take this product 1.0g, 5ml hydrochloric acid dissolved in 23ml of water, according to inspection, should meet the requirements (0.0002%).
Chloride: Ethyl lactate product 0.10g, according to inspection, made with standard sodium chloride solution 5.0ml control solution may not be thicker (0.050%).
Sulfate: Take this product 0.40g, according to inspection, made with standard potassium sulfate solution 3.0ml control solution may not be thicker (0.075%).
Barium salt: Take 1.0g, 20ml water to dissolve, is divided into two equal parts, one as a control tube, another plus calcium sulfate solution 1ml, for 15 minutes, compared with the control tube, not thicker.
Molysite: Take this product 0.50g, add water 25ml, dissolved by heating in a water bath, zinc lactate, according to inspection, with the standard iron solution 2.5ml were made using the same method was compared to no deeper (0.005%).
Heavy Metal: Take this product 1.0g, add water 15ml with acetate buffer (pH3.5) 2ml micro heat dissolved, let cool, add water to make into a 25ml, according to inspection, containing heavy metals should not exceed ten millionths.
Arsenic: take this product 1.0g, 5ml hydrochloric acid dissolved in 23ml of water, according to inspection, should meet the requirements (0.0002%).
Lactate Nutrition
Used as a nutrient supplement for calcium, calcium lactate, cakes and other buffering agents, leavening agent. Also be used for bread, cakes, pasta, powdered milk market system, tofu, miso, pickled products. As with other calcium supplements which are easily absorbed. As drug use, can prevent calcium deficiency disease, such as rickets, potassium lactate, and women's pregnancy and lactation required calcium supplement.
Preparation of calcium lactate
Gelatinization of rice by high pressure, diluted with water cooled to 50-53 ℃, access Aspergillus and Zinc lactate delbrueckii, lactic acid fermentation metabolites, calcium phosphate and then added to obtain a crude calcium lactate, and finally purified, or with calcium carbonate and dilute acid solution, and then the solution was evaporated in the system. Refining process is the use of magnesium hydroxide and ferrous lactate reacts with calcium, it is the nature of cohesion, so that part of the fermentation broth and protein impurities removed after condensation, and then concentrated in vacuo, crystallization, refining lactate.
2013年7月28日星期日
Potassium citrate anti-calculus
Oral potassium citrate on a ketogenic diet for children, it is a supplement effective in preventing ferrous lactate, urine alkalinization can achieve the goal, it is worth a full complement.
But the study's lack of randomization.
The study authors concluded that we recommend to start using the ketogenic diet, education about the importance of regular supplement of potassium citrate, and then at each visit to emphasize buffered lactic acid. More research will help confirm whether high doses of potassium citrate can completely prevent or used in combination with other supplements such as multivitamins, to increase compliance.
But the study's lack of randomization.
The study authors concluded that we recommend to start using the ketogenic diet, education about the importance of regular supplement of potassium citrate, and then at each visit to emphasize buffered lactic acid. More research will help confirm whether high doses of potassium citrate can completely prevent or used in combination with other supplements such as multivitamins, to increase compliance.
Potassium citrate research
The study sample consisted of 313 daily potassium lactate indications meet children in 2000-2008 between the Johns Hopkins Hospital began eating ketogenic diet, each child received at least one month of follow-up. 2000-2005, the ketogenic diet for children hypercalciuria occurs, these children receive a daily dose of 2 mEq per kg. From 2006, all children receiving the ketogenic diet are empirically using potassium citrate.
198 Use of potassium citrate in the prevention of child 4 (2.0%), 105 did not use potassium citrate children 11 (10.5%) occurred kidney stones (P = 0.003). Beginning in 2006, two children refused to supplement potassium citrate; these two children have an occurrence of magnessium lactate. Before you start using the ketogenic diet, the success of children receiving prophylactic potassium citrate, 0.9% incidence of kidney stones (1/106), because of the high calcium before accepting potassium citrate is 6.7% (13 / 195).
Although children receiving potassium citrate compare alkaline urine (mean pH 6.8 compared to 6.2; P = 0.002), but this group has not decreased blood pH. Potassium citrate was well tolerated and no significant side effects.
198 Use of potassium citrate in the prevention of child 4 (2.0%), 105 did not use potassium citrate children 11 (10.5%) occurred kidney stones (P = 0.003). Beginning in 2006, two children refused to supplement potassium citrate; these two children have an occurrence of magnessium lactate. Before you start using the ketogenic diet, the success of children receiving prophylactic potassium citrate, 0.9% incidence of kidney stones (1/106), because of the high calcium before accepting potassium citrate is 6.7% (13 / 195).
Although children receiving potassium citrate compare alkaline urine (mean pH 6.8 compared to 6.2; P = 0.002), but this group has not decreased blood pH. Potassium citrate was well tolerated and no significant side effects.
Potassium citrate storage
Transport packaging should be kept intact, waterproof, moisture-proof, non-toxic materials transportation mix with and mix should be stored in a cool, dry and ventilated place.
From the date of the product from the factory in line with the standards required storage conditions, storage period of one and calcium lactate.
Potassium citrate is a daily use, you can make the urine alkaline urine and oral supplements of calcium leaching solution, Calcium lactate, can reduce the risk of kidney stones. Recent Johns Hopkins University in Baltimore, Maryland School of Medicine, Dr. Melanie A. McNally study noted that in children receiving the ketogenic diet, about 6% of kidney stones.
The study sample consisted of 313 daily potassium citrate indications meet children in 2000-2008 between the Johns Hopkins Hospital began eating ketogenic diet, each child received at least one month of follow-up. 2000-2005, the ketogenic diet for children hypercalciuria occurs, these children receive a daily dose of 2 mEq per kg. From 2006, all children receiving the ketogenic diet are empirically using potassium citrate.
From the date of the product from the factory in line with the standards required storage conditions, storage period of one and calcium lactate.
Potassium citrate is a daily use, you can make the urine alkaline urine and oral supplements of calcium leaching solution, Calcium lactate, can reduce the risk of kidney stones. Recent Johns Hopkins University in Baltimore, Maryland School of Medicine, Dr. Melanie A. McNally study noted that in children receiving the ketogenic diet, about 6% of kidney stones.
The study sample consisted of 313 daily potassium citrate indications meet children in 2000-2008 between the Johns Hopkins Hospital began eating ketogenic diet, each child received at least one month of follow-up. 2000-2005, the ketogenic diet for children hypercalciuria occurs, these children receive a daily dose of 2 mEq per kg. From 2006, all children receiving the ketogenic diet are empirically using potassium citrate.
Potassium citrate packaging and marking
Mark
Bags should be strong, clear signage manufacturer shall state the name, address, product names, Zinc lactate, the standard number, batch number, production date, net weight and the "food additive" words.
Package
Food additive potassium citrate lined with ferrous lactate polyethylene film and double kraft paper or double food-grade polyethylene film bag for inner packing, packaging plastic bags. Net weight 25kg, loading volume tolerance of ± 0.5%, can be packed according to user needs.
Bags should be strong, clear signage manufacturer shall state the name, address, product names, Zinc lactate, the standard number, batch number, production date, net weight and the "food additive" words.
Package
Food additive potassium citrate lined with ferrous lactate polyethylene film and double kraft paper or double food-grade polyethylene film bag for inner packing, packaging plastic bags. Net weight 25kg, loading volume tolerance of ± 0.5%, can be packed according to user needs.
Potassium citrate acceptance criteria
Food additive potassium citrate manufacturer technical department should be tested. Manufacturer shall ensure that all manufactured products are compliant with the requirements of this standard, Zinc lactate of products shall be accompanied by quality certification, including: manufacturer name, product name, batch number, date of manufacture, net weight, the standard number and so on.
The use of units entitled to the provisions of this standard, the quality of the received product acceptance, the results are consistent with our standards.
Each batch weight does not exceed 2t.
According to GB 6678 GB 6679 in 6.6 and 2.3.1 stipulates that in sampling. Sampling shall not be less than the total amount of 500g, should be thoroughly mixed, were stored in two clean, magnessium lactate, airtight container, to label manufacturer name, product name, batch number, date. Copy for inspection by, leaving a kind of reference, stay kind of period of six months.
If the test results do not meet any of the requirements of this standard should be re-double the amount of packaging from the sample retest. Re-test results even if only one does not meet standards, the entire batch of products to be ineligible.
When the supply and demand sides of product quality occurs dissent, press the "National Product Quality Inspection arbitration Interim Measures," "the regulations.
The use of units entitled to the provisions of this standard, the quality of the received product acceptance, the results are consistent with our standards.
Each batch weight does not exceed 2t.
According to GB 6678 GB 6679 in 6.6 and 2.3.1 stipulates that in sampling. Sampling shall not be less than the total amount of 500g, should be thoroughly mixed, were stored in two clean, magnessium lactate, airtight container, to label manufacturer name, product name, batch number, date. Copy for inspection by, leaving a kind of reference, stay kind of period of six months.
If the test results do not meet any of the requirements of this standard should be re-double the amount of packaging from the sample retest. Re-test results even if only one does not meet standards, the entire batch of products to be ineligible.
When the supply and demand sides of product quality occurs dissent, press the "National Product Quality Inspection arbitration Interim Measures," "the regulations.
Determination of loss on drying
Weigh 1.5g sample, accurate to 0.0002g, remaining with the requirements according to GB6284, drying temperature of 180 ± 2 ℃. Dry matter after drying the sample A, reserved for determination of Sodium lactate.
Take two parallel tests for the determination of the arithmetic mean of the results, the difference between the results of two parallel determinations shall not be greater than 0.1%.
Sulfate (SO4) Determination
Weigh 0.2g sample was measured according to lactic acid powder procedures sulphate (SOP-ZL-0402-00) detected as SO4 not exceed 1000PPM.
Chloride (Cl) Determination
Weigh 0.2g sample, according to the determination of chloride standard operating procedures (SOP-ZL-0401-00) detected as Cl does not exceed 200PPM.
Iron (Fe) Determination
Weigh 1.0g sample was measured according to standard operating procedures ferric (SOP-ZL-0403-00) detected as Fe does not exceed 10PPM.
Take two parallel tests for the determination of the arithmetic mean of the results, the difference between the results of two parallel determinations shall not be greater than 0.1%.
Sulfate (SO4) Determination
Weigh 0.2g sample was measured according to lactic acid powder procedures sulphate (SOP-ZL-0402-00) detected as SO4 not exceed 1000PPM.
Chloride (Cl) Determination
Weigh 0.2g sample, according to the determination of chloride standard operating procedures (SOP-ZL-0401-00) detected as Cl does not exceed 200PPM.
Iron (Fe) Determination
Weigh 1.0g sample was measured according to standard operating procedures ferric (SOP-ZL-0403-00) detected as Fe does not exceed 10PPM.
Determination of alkalinity
Reagents and materials
a, hydrochloric acid standard titration Sodium lactate: c (HCl) = 0.1mol / L;
b, phenolphthalein indicator solution: 10g / L.
Analysis step
Weigh 1.0g sample, accurate to 0.01g, no carbon dioxide dissolved in 20mL of water, add 1 drop of phenolphthalein indicator solution, the solution should be pink. Add 0.4mL hydrochloric ferrous lactate volumetric solution, pink disappears.
Arsenic (As) determination
1.0g sample weighed to the nearest 0.01g, was dissolved in 25mL water, as the sample solution. Press GB8450 rest of "Gutzeit method". And arsenic (As) 3μg comparison arsenic standard solution.
Heavy metals (as Pb) Determination
1.0g sample weighed to the nearest 0.01g, was dissolved in 25mL water, as the sample solution. Press the remaining provisions of GB8451. And lead (Pb) 10μg of lead standard solution to compare.
a, hydrochloric acid standard titration Sodium lactate: c (HCl) = 0.1mol / L;
b, phenolphthalein indicator solution: 10g / L.
Analysis step
Weigh 1.0g sample, accurate to 0.01g, no carbon dioxide dissolved in 20mL of water, add 1 drop of phenolphthalein indicator solution, the solution should be pink. Add 0.4mL hydrochloric ferrous lactate volumetric solution, pink disappears.
Arsenic (As) determination
1.0g sample weighed to the nearest 0.01g, was dissolved in 25mL water, as the sample solution. Press GB8450 rest of "Gutzeit method". And arsenic (As) 3μg comparison arsenic standard solution.
Heavy metals (as Pb) Determination
1.0g sample weighed to the nearest 0.01g, was dissolved in 25mL water, as the sample solution. Press the remaining provisions of GB8451. And lead (Pb) 10μg of lead standard solution to compare.
2013年7月26日星期五
L lactate
Calcium lactate in the "L" is in English, "Left" shorthand, meaning "left" means, L-structure is a creature that can be identified, the structure of biologically active compounds. L-type calcium L-body structure with consistent, so it is a highly soluble calcium source, easily absorbed, is a new type of calcium supplement. With ferrous lactate as the main raw material of health food, health care function with calcium. The main raw material Ethyl lactate, sugar, skimmed milk powder, starch, citric acid, orange oil, L-lactate than domestic sources, mostly domestic instability L-lactic acid, and calcium in the synthesis, it will affect calcium absorption.
L calcium lactate and calcium lactate difference
L lactate white crystalline powder, no odor, solubility than calcium lactate, insoluble in organic solvents, L-lactate as L-lactate, easily soluble in water (solubility than calcium lactate good).
Calcium absorbed by the body in the case of buffered lactic acid can regulate the human microcirculation, no DL-lactate fermentation sour smell, compared with DL-lactate greater use value compared
L-lactate is mainly used for food additives, supplement the body calcium, breads, pastries and other buffering agents, leavening agents, calcium supplements. Widely used in food, lactic acid powder, pharmaceutical and other industries. As a nutrient supplement dosage according to GB14880-94 and GB2760 requirements
Calcium lactate is a good food calcium supplements, calcium absorption better than inorganic. Can be used in infant food, usage is 23 ~ 46g/kg; in grains and their products for 12 ~ 24g/kg;, drinking fluids and milk drinks for 3 ~ 6g/kg. Also leavening agent for bread baking powder and buffers
Calcium absorbed by the body in the case of buffered lactic acid can regulate the human microcirculation, no DL-lactate fermentation sour smell, compared with DL-lactate greater use value compared
L-lactate is mainly used for food additives, supplement the body calcium, breads, pastries and other buffering agents, leavening agents, calcium supplements. Widely used in food, lactic acid powder, pharmaceutical and other industries. As a nutrient supplement dosage according to GB14880-94 and GB2760 requirements
Calcium lactate is a good food calcium supplements, calcium absorption better than inorganic. Can be used in infant food, usage is 23 ~ 46g/kg; in grains and their products for 12 ~ 24g/kg;, drinking fluids and milk drinks for 3 ~ 6g/kg. Also leavening agent for bread baking powder and buffers
milk calcium lactate difference
Milk calcium is extracted from milk natural substances, which contains milk protein separation and purification from a natural physiologically active peptide cPP (casein phosphopeptide), can promote the body's absorption of calcium. 0-6 years old baby are more suitable. It must be noted, milk calcium itself unsaturated fatty acid content of less and. And calcium, phosphorus ratio properly, which may affect the baby's absorption of calcium.
Calcium lactate is generally made from natural food produced by submerged fermentation of Calcium lactate and calcium consumption through a combination of scientific methods. Since magnessium lactate L-physiological characteristics of the human body generally consistent, and high solubility. Into the human body can be acidified human gastrointestinal tract, improve the utilization of calcium, 0 to 6 years old baby is very suitable.
Calcium lactate is generally made from natural food produced by submerged fermentation of Calcium lactate and calcium consumption through a combination of scientific methods. Since magnessium lactate L-physiological characteristics of the human body generally consistent, and high solubility. Into the human body can be acidified human gastrointestinal tract, improve the utilization of calcium, 0 to 6 years old baby is very suitable.
Calcium lactate - Determination
To about 0.3g, accurately weighed, add water 100ml, heated to dissolve,
Sodium lactate, add sodium hydroxide solution 15ml with calcium purpurin indicator about 0.1g, with ethylene diamine tetra-acetic acid disodium titrant (0.05 mol / L) titration until the solution changes from purple to pure blue. Each 1ml of ethylene diamine tetra acetic acid disodium titrant (0.05mol / L) is equivalent to 15.42mg of C6H10CaO6 · 5H2O. Slightly hazardous for water Do not allow undiluted product or large quantities of it to reach ground water, water course or magnessium lactate, without proper governmental permits do not allow material to be released to the environment.
Sodium lactate, add sodium hydroxide solution 15ml with calcium purpurin indicator about 0.1g, with ethylene diamine tetra-acetic acid disodium titrant (0.05 mol / L) titration until the solution changes from purple to pure blue. Each 1ml of ethylene diamine tetra acetic acid disodium titrant (0.05mol / L) is equivalent to 15.42mg of C6H10CaO6 · 5H2O. Slightly hazardous for water Do not allow undiluted product or large quantities of it to reach ground water, water course or magnessium lactate, without proper governmental permits do not allow material to be released to the environment.
Calcium lactate - content detection
Acidity: take this product 1.0g, add boiling over dissolved in 20ml warm water, let cool, add 2 drops of phenolphthalein indicator solution and sodium hydroxide solution (0.1mol / L) 0.50ml, should be significantly pink.
Chloride: Take this product 0.10g, according to inspection, made with standard ferrous lactate solution 5.0ml control solution may not be thicker (0.050%).
Sulfate: Take this product 0.40g, according to inspection, made with standard potassium sulfate solution 3.0ml control solution may not be thicker (0.075%).
Barium salt: Take 1.0g, 20ml water to dissolve, is divided into two equal parts, one as a control tube, another plus calcium sulfate solution 1ml, for 15 minutes, compared with the control tube, not thicker.
Molysite: Take this product 0.50g, add water 25ml, dissolved by heating in a water bath, buffered lactic acid, according to inspection, with the standard iron solution 2.5ml were made using the same method was compared to no deeper (0.005%).
Heavy Metal: Take this product 1.0g, add water 15ml with acetate buffer (pH3.5) 2ml micro heat dissolved, let cool, add water to make into a 25ml, according to inspection, containing heavy metals should not exceed ten millionths.
Arsenic: take this product 1.0g, 5ml hydrochloric acid dissolved in 23ml of water, according to inspection, should meet the requirements (0.0002%).
Chloride: Take this product 0.10g, according to inspection, made with standard ferrous lactate solution 5.0ml control solution may not be thicker (0.050%).
Sulfate: Take this product 0.40g, according to inspection, made with standard potassium sulfate solution 3.0ml control solution may not be thicker (0.075%).
Barium salt: Take 1.0g, 20ml water to dissolve, is divided into two equal parts, one as a control tube, another plus calcium sulfate solution 1ml, for 15 minutes, compared with the control tube, not thicker.
Molysite: Take this product 0.50g, add water 25ml, dissolved by heating in a water bath, buffered lactic acid, according to inspection, with the standard iron solution 2.5ml were made using the same method was compared to no deeper (0.005%).
Heavy Metal: Take this product 1.0g, add water 15ml with acetate buffer (pH3.5) 2ml micro heat dissolved, let cool, add water to make into a 25ml, according to inspection, containing heavy metals should not exceed ten millionths.
Arsenic: take this product 1.0g, 5ml hydrochloric acid dissolved in 23ml of water, according to inspection, should meet the requirements (0.0002%).
Calcium lactate - The main purpose
Used as a nutrient supplement for calcium, for bread, cakes and other buffering agents, leavening agent. Also be used for bread, Lactic acid, pasta, powdered milk market system, tofu, magnessium lactate, pickled products. As with other calcium supplements which are easily absorbed. As drug use, can prevent calcium deficiency disease, such as rickets, tetany, and women's pregnancy and lactation required calcium supplement.
Calcium lactate - Preparation
Gelatinization of rice by high pressure, diluted with water cooled to 50-53 ℃, access Aspergillus and Lactobacillus delbrueckii, potassium lactate fermentation metabolites, calcium phosphate and then added to obtain a crude calcium lactate, and finally purified, or with calcium carbonate and magnessium lactate, and then the solution was evaporated in the system. Refining process is the use of magnesium hydroxide and magnesium hydroxide reacts with calcium, it is the nature of cohesion, so that part of the fermentation broth and protein impurities removed after condensation, and then concentrated in vacuo, crystallization, refining lactate.
2013年7月25日星期四
The molecular structure of calcium lactate
Lactate, the formula [CH3CHOHCOO] 2Ca · 5H2O. White granules or powder,
zinc lactate, slight weathering, soluble in water, insoluble in ethanol, ether and chloroform. Has a high solubility, dissolution speed, high bioavailability, good taste, is widely used in dairy, beverage, food, health care products and other fields.
Lactate, molecular structure simplified formula [CH3CH (OH) COO] 2Ca · 5H2O. White breeze resistance granules or buffered lactic acid. Soluble in water, practically insoluble in ethanol, ether and chloroform. Odorless, tasteless. At 120 ℃, crystallization of water lost.
zinc lactate, slight weathering, soluble in water, insoluble in ethanol, ether and chloroform. Has a high solubility, dissolution speed, high bioavailability, good taste, is widely used in dairy, beverage, food, health care products and other fields.
Lactate, molecular structure simplified formula [CH3CH (OH) COO] 2Ca · 5H2O. White breeze resistance granules or buffered lactic acid. Soluble in water, practically insoluble in ethanol, ether and chloroform. Odorless, tasteless. At 120 ℃, crystallization of water lost.
high-calorie yogurt drink milk that
As the years have been the benefits of yogurt on human attention, plus many manufacturers are very optimistic about this market segment,ferrous lactate, the introduction of many species, so that people have more choices.
Yogurt and milk in different places mainly because it added lactic acid bacteria, so the milk sugar lactose is broken down into lactic acid, while the study found that lactic acid and calcium binding, the most easily absorbed by the body, so it is suitable for yogurt the developing adolescent or adolescent menopausal osteoporosis is easy for women to drink. In addition, it created a gastrointestinal acidic environment, but also helps the absorption of iron.
Mention the heat, we must understand its composition. Although each brand is different, but most of the content is nothing more than contain milk, pectin, fructose and spices. Sodium lactate generally not suited to be too sour yogurt, so manufacturers will add sugar or fructose to taste, and thus increase the number of calories.
240cc low-fat milk contains about 120 calories, while the same amount of low-fat yogurt, but contains 150-200 calories (according to each brand is different), so much more heat than to imagine. If you want to drink fewer calories yogurt, skim'd recommend that you select Mark, and low-calorie yogurt, because the same 240cc only contains 100 calories or so calories.
Yogurt and milk in different places mainly because it added lactic acid bacteria, so the milk sugar lactose is broken down into lactic acid, while the study found that lactic acid and calcium binding, the most easily absorbed by the body, so it is suitable for yogurt the developing adolescent or adolescent menopausal osteoporosis is easy for women to drink. In addition, it created a gastrointestinal acidic environment, but also helps the absorption of iron.
Mention the heat, we must understand its composition. Although each brand is different, but most of the content is nothing more than contain milk, pectin, fructose and spices. Sodium lactate generally not suited to be too sour yogurt, so manufacturers will add sugar or fructose to taste, and thus increase the number of calories.
240cc low-fat milk contains about 120 calories, while the same amount of low-fat yogurt, but contains 150-200 calories (according to each brand is different), so much more heat than to imagine. If you want to drink fewer calories yogurt, skim'd recommend that you select Mark, and low-calorie yogurt, because the same 240cc only contains 100 calories or so calories.
yogurt nutrition and health
Yogurt, generally refers to yogurt, which is based on fresh milk as raw material, through Markov sterilized milk and then add to the beneficial bacteria (starter), the hair alcohol, then cooled filling a milk product. Yogurt products on the market today mostly solidified, stirred and lactic acid powder of accessories such as fruit juice jam type as much. Yogurt in addition to nutritious, but also contains lactic acid bacteria, and therefore have a role in health care. These effects are:
1, maintain the ecological balance of intestinal flora, forming a biological barrier, inhibiting the invasion of harmful bacteria in the gut.
2, by generating a large number of short-chain fatty acids promote intestinal motility and bacterial massive growth and change in osmotic pressure to prevent constipation.
3, yogurt contains a variety of enzymes, magnessium lactate and absorption.
4, by inhibiting the growth of saprophytic bacteria in the intestine, inhibits corruption occurring toxins, the liver and brain damage from these toxins and prevent aging.
5, by inhibiting the saprophytic bacteria and the growth of certain bacteria in the intestine. Thus inhibiting these bacteria produced carcinogen, to anti-cancer purposes.
6, improve immune function, lactic acid bacteria can produce some substances to enhance immune function, can improve the body immunity, prevent disease.
1, maintain the ecological balance of intestinal flora, forming a biological barrier, inhibiting the invasion of harmful bacteria in the gut.
2, by generating a large number of short-chain fatty acids promote intestinal motility and bacterial massive growth and change in osmotic pressure to prevent constipation.
3, yogurt contains a variety of enzymes, magnessium lactate and absorption.
4, by inhibiting the growth of saprophytic bacteria in the intestine, inhibits corruption occurring toxins, the liver and brain damage from these toxins and prevent aging.
5, by inhibiting the saprophytic bacteria and the growth of certain bacteria in the intestine. Thus inhibiting these bacteria produced carcinogen, to anti-cancer purposes.
6, improve immune function, lactic acid bacteria can produce some substances to enhance immune function, can improve the body immunity, prevent disease.
full of lactic acid bacteria - 30 billion outstanding performance
Wei Chuan spirit of modern gastrointestinal health care, dedicated people to build healthy digestive health drinks as the goal, in 2002 launched Wei Chuan ferrous lactate bacteria drinks, 2005, Wei Chuan lactic flavor drinks 100ml bottle that access to national health food certification. Wei Chuan probiotic lactobacillus rich from the famous Academy of Sciences Institute of Danmaihansen LC01 viable, can easily reach through the stomach acid test gut, regulation of intestinal flora, to better help the absorption of nutrients, while adding precious gold double discrimination factor, dual benefits with drink after a meal to help digestion, gastrointestinal health care. Daily consumption, more proliferation of beneficial bacteria in the intestines, to digestive stream of power.
2010 new upgrade Wei Chuan lactobacillus drinks per vial (100 ml) of up to 30 billion viable cells. Ethyl lactate the Chinese Preventive Medical Association magazine published clinical research papers indicate, for taking Wei Chuan lactic acid bacteria drinks, daily 200ml, improved digestion of the gastrointestinal tract, as well as the improvement and adjustment of mild constipation gut microflora environment has significant effect, significantly better than the current market 10,000,000,000 content of lactic acid bacteria beverages. This means and the "10 billion" compared to "30 billion" will better protect human intestinal health.
2010 new upgrade Wei Chuan lactobacillus drinks per vial (100 ml) of up to 30 billion viable cells. Ethyl lactate the Chinese Preventive Medical Association magazine published clinical research papers indicate, for taking Wei Chuan lactic acid bacteria drinks, daily 200ml, improved digestion of the gastrointestinal tract, as well as the improvement and adjustment of mild constipation gut microflora environment has significant effect, significantly better than the current market 10,000,000,000 content of lactic acid bacteria beverages. This means and the "10 billion" compared to "30 billion" will better protect human intestinal health.
lactic acid bacteria drinks into consumer darling
Nowadays, "lactic acid bacteria beverage" Following the milk, yogurt after being quietly become the Zinc lactate of the consumer. In modern society, mental stress increases, coupled with irrational diet, environmental pollution and other factors, cause the body to reduce intestinal bacteria, intestinal microflora disorders, making China the incidence of intestinal diseases and the emergence of a younger age to rise year after year trend. Scientific evidence, buffered lactic acid bacteria drinks can effectively improve digestion, elimination of intestinal waste, enhance human immunity and resistance. Now, many urban residents have gradually develop a long-term consumption of lactic acid bacteria to help digestion habits.
Calcium Lactate Product
Lactate used for infant nutrition research and development. According to modern preventive medicine theory, developed a scientific calcium lactate microcrystalline powder, is based on the physiological characteristics of children developed tailor calcium microcrystalline powder magnessium lactate, microcrystalline powder is more suitable for children's delicate stomach, easier to absorb and digest. Especially with vitamin D and a variety of efficient probiotic growth factor - bifidus factor (FOS, GOS) as the absorption enhancers, and the use of advanced biological extraction technology cryogenic purification production workshop in one hundred thousand refined and calcium lactate; quality fine distinctions, prescriptions science, on the calcium absorption rate went up to a new level, make the baby easily absorbed. Brewed convenient, widely respected and young parents won great favor for you to feed your baby more scientific and professional service.
particles of calcium lactate drug interactions
1. The drug should not be with digitalis drugs. (2) a lot of drinking alcoholic and caffeinated beverages and Calcium lactate, will inhibit the absorption of calcium. 3 large number of eating foods rich in fiber can inhibit the absorption of calcium, because calcium is not easily absorbed into the cellulose binding compounds. 4 The tetracycline drugs with phenytoin and similar use, both to reduce the absorption. 5 vitamin D, Zinc lactate, estrogen can increase the absorption of calcium. 6 aluminum-containing antacids medicines with the same service, the increased absorption of aluminum. 7 of the drug in combination with thiazide diuretics, prone to hypercalcemia (due to increased renal tubular reabsorption of calcium). 8 of the drug in combination with potassium-containing drugs, they should pay attention to the incidence of arrhythmias. 9 used simultaneously with other drugs may occur drug interactions, please consult your physician or pharmacist.
manufacture vitamins
manufacture vitamins:
Lactic acid bacteria in the gut can produce the human body needs vitamins, such as vitamin k, b2, b6, b12, folic acid.
Lactobacillus species lactic acid powder acidophilus and with bifidobacteria affects the human body the most significant, their main function is to boost the immune regulation, enhance the body's resistance to intestinal infection, reduce diarrhea and helps generate vitamin b group and k has strengthened the absorption of calcium, Sodium lactate, potassium, etc.
Commercially available products containing lactic acid bacteria, generally refers to fermented milk beneficial fungi, which is mainly used in the composition of milk and sugar, after the lactic acid fermentation process made. Most of these products can help to emphasize and maintain the balance of beneficial bacteria in the human body to achieve health.
Lactic acid fermentation of lactose in milk can be broken down to only 20-30% original content of drinking milk will cause diarrhea so people can use this type of lactic acid drinks instead of milk, but absorption into the same nutrients.
Further, since the lactic acid bacteria in milk like casein and become more digestible fat, also helps calcium in milk and lactic acid combined more easily absorbed by the intestinal environment showing a result of the influence of lactic acid, for the entire digestion and stomach intestine have helped.
Lactic acid bacteria in the gut can produce the human body needs vitamins, such as vitamin k, b2, b6, b12, folic acid.
Lactobacillus species lactic acid powder acidophilus and with bifidobacteria affects the human body the most significant, their main function is to boost the immune regulation, enhance the body's resistance to intestinal infection, reduce diarrhea and helps generate vitamin b group and k has strengthened the absorption of calcium, Sodium lactate, potassium, etc.
Commercially available products containing lactic acid bacteria, generally refers to fermented milk beneficial fungi, which is mainly used in the composition of milk and sugar, after the lactic acid fermentation process made. Most of these products can help to emphasize and maintain the balance of beneficial bacteria in the human body to achieve health.
Lactic acid fermentation of lactose in milk can be broken down to only 20-30% original content of drinking milk will cause diarrhea so people can use this type of lactic acid drinks instead of milk, but absorption into the same nutrients.
Further, since the lactic acid bacteria in milk like casein and become more digestible fat, also helps calcium in milk and lactic acid combined more easily absorbed by the intestinal environment showing a result of the influence of lactic acid, for the entire digestion and stomach intestine have helped.
lactic acid bacteria
① help digestion and maintain intestinal health:
Lactic acid bacteria can help digestion, adjust large intestine motility, in order to facilitate bowel functioning. In addition, magnessium lactate can also help calcium absorption.
② prevent diarrhea:
When traveling, often due to lack of acclimatization which causes diarrhea or vomiting, you can go out taking lactobacillus food; Or originally balanced intestinal flora ecological destruction resulting from diarrhea, you can also add a lot of lactic acid bacteria, keeping the body flora ecological balance.
③ prevention of cancer:
Growth of calcium lactate bacteria in the gastrointestinal tract, due to anti-microbial populations antagonistic effect, would produce a significant reduction of carcinogens bad bacteria, thereby reducing the chances of cancer.
④ eliminate constipation:
Lactic acid can increase the secretion of large intestine motility, and the role of mild nature, unlike the market laxatives.
Lactic acid bacteria can help digestion, adjust large intestine motility, in order to facilitate bowel functioning. In addition, magnessium lactate can also help calcium absorption.
② prevent diarrhea:
When traveling, often due to lack of acclimatization which causes diarrhea or vomiting, you can go out taking lactobacillus food; Or originally balanced intestinal flora ecological destruction resulting from diarrhea, you can also add a lot of lactic acid bacteria, keeping the body flora ecological balance.
③ prevention of cancer:
Growth of calcium lactate bacteria in the gastrointestinal tract, due to anti-microbial populations antagonistic effect, would produce a significant reduction of carcinogens bad bacteria, thereby reducing the chances of cancer.
④ eliminate constipation:
Lactic acid can increase the secretion of large intestine motility, and the role of mild nature, unlike the market laxatives.
Benefits of Lactobacillus
The role of lactic acid bacteria has been recognized by the medical community. In recent years, according to research data shows that: lactic acid bacteria as beneficial bacteria in the gut to settle a variety of health effects: 1. Maintain intestinal microflora balance and function. buffered lactic acid bacteria in the intestinal tract through the metabolism of lactic acid, can inhibit the growth of harmful bacteria and reproduce, maintain ecological balance and intestinal normal intestinal function, can stimulate the intestinal peristalsis, increasing stool water content, laxative, this feature is in line with the required clearing garbage gut, but it ulcers,zinc lactate, diarrhea, constipation is also a significant therapeutic effect. (2) have an antibacterial effect, can inhibit spoilage bacteria, such as Listeria can kill bacteria, staphylococci and Leuconostoc, to suppress and eliminate Gram-negative bacteria, catalase-positive bacteria, such as E. coli and salmonella. 3 can improve liver function. The reason is that restraint spoilage lactic acid bacteria, detoxify the liver to reduce the heavy load. Further, since the PH value can be reduced, can not easily absorbed ammonia into a plasma state. 4 of lactic acid bacteria can reduce intestinal absorption of cholesterol, and can part of cholesterol into bile salts excreted. 5 can enhance immune function and anti-tumor disease. This is because the lactic acid bacteria make carcinogenic nitrosamines intestinal absorption rate up to 98%, can reduce the incidence of colorectal cancer. Lactic acid bacteria can also stimulate the intestinal lymph nodes, boosts the immune cells and macrophage activity, as pathogenic bacteria
2013年7月24日星期三
PLA area
Disposable supplies in the areaPolylactide absolutely harmless to human body characteristics make polylactic acid in disposable tableware, disposable food packaging materials and other supplies in the area has a unique advantage. It can also completely biodegradable meet the world, especially the European Union, the United States and Japan, the high demand for environmental protection. However, the use of polylactic acid material being processed does not exist disposable tableware temperature, oil and other defects. This resulted in significantly reducing the effectiveness of its functions, as well as in transit cutlery deformation, brittle material, resulting in a large number of defects. However, through the technical development, the market has been modified Zinc lactate that can overcome the shortcomings of the original grain, some even heat resistance up to 120 degrees, can be used for microwave equipment material.
Biomedical field
Bio-pharmaceutical industry is the first to carry out polylactide application areas. Polylactic acid on human security can be highly absorbed by tissue, combined with its excellent physical and mechanical properties, can also be applied in the biomedical field, such as magnessium lactate infusion set, to avoid demolition-type surgical sutures, drug relief package agents, artificial fractures fixation materials, tissue repair materials, such as artificial skin. High molecular weight polylactic acid has a very high mechanical properties, in Europe and other countries have been used instead of stainless steel, as a new type of orthopedic fixation materials such as bone screws, bone plates are heavily used, which can be absorbed by the body metabolism characteristics make patients from secondary pain of surgery. Its technology and high added value, the medical industry, the development prospects of polymer materials.
Biomedical field
Bio-pharmaceutical industry is the first to carry out polylactide application areas. Polylactic acid on human security can be highly absorbed by tissue, combined with its excellent physical and mechanical properties, can also be applied in the biomedical field, such as magnessium lactate infusion set, to avoid demolition-type surgical sutures, drug relief package agents, artificial fractures fixation materials, tissue repair materials, such as artificial skin. High molecular weight polylactic acid has a very high mechanical properties, in Europe and other countries have been used instead of stainless steel, as a new type of orthopedic fixation materials such as bone screws, bone plates are heavily used, which can be absorbed by the body metabolism characteristics make patients from secondary pain of surgery. Its technology and high added value, the medical industry, the development prospects of polymer materials.
Other grades of PLA resin
Biaxially stretched film is by far the most successful PLA film after biaxially stretched and heat set temperature resistant Sodium lactate can be increased to 90 ℃, just to make this defect is not high temperature of PLA. Through the two-way stretch orientation and the adjustment setting process can also control BOPLA membrane sealing temperature at 70 ~ 160 ℃. This advantage is not available in ordinary BOPET. In addition, BOPLA film transmittance of 94%, low haze, surface gloss is also very good, such membranes can be used for flower packaging,lactic acid powder, transparent window film, candy wrappers and so on.
PLA nonwoven fabric has been used is the spunbond nonwovens, plastic limit because of China's implementation of the non-woven shopping bags used for the production of the more popular. The blown film, lamination these two areas are some of the features because of defects PLA itself, applications still further exploration, some successful application cases is to use the modified PLA.
PLA nonwoven fabric has been used is the spunbond nonwovens, plastic limit because of China's implementation of the non-woven shopping bags used for the production of the more popular. The blown film, lamination these two areas are some of the features because of defects PLA itself, applications still further exploration, some successful application cases is to use the modified PLA.
PLA injection molding grade resin
In PLA injection molding market applications, the more widely used is the modified resins. Although pure PLA has high transparency, ferrous lactate, etc., but its hard and brittle, difficult process and does not affect its heat and other shortcomings in the application of injection molding. Of course, the chemical, plastics industry are committed to solve these problems. For example, using the BPM-500 This additive can improve the impact strength of PLA; adding a small amount called Biomax Strong vinyl copolymer can improve the toughness of the PLA; with another PHA biodegradable resin blends can improve some of the PLA performance; addition, Japanese Scientists then developed a heat-resistant PLA resin pulp added. Some of the ways the above polylactic acid modified products at the expense of the transparency, but it improves the heat resistance of polylactic acid, buffered lactic acid, impact resistance and other aspects of defects and improve the ease of its processing, the application range been expanded. In injection molding grade resin sea is about 70% of sales for the modified polylactic acid.
And on the whole, relatively high cost is impeding PLA widely used in the injection molding market, the biggest reason. Although pure resin modified by filling in some of the cost can be reduced, but to ensure its performance under the premise of the role of this measure is limited, if you need to, under the premise that biodegradable PLA improve performance deficiencies, such as heat performance, cost is even higher.
And on the whole, relatively high cost is impeding PLA widely used in the injection molding market, the biggest reason. Although pure resin modified by filling in some of the cost can be reduced, but to ensure its performance under the premise of the role of this measure is limited, if you need to, under the premise that biodegradable PLA improve performance deficiencies, such as heat performance, cost is even higher.
PLA extrusion grade resin
PLA extrusion grade resins are the major market applications, mainly for large supermarket fresh produce packaging, packaging has become such an important European market chain one; Calcium lactate advocate for safety, energy conservation, environmental protection, electronics packaging on. In these applications, PLA high transparency, high gloss, high rigidity, etc. reflected most vividly, is already the dominant direction of the PLA application. In addition, extrusion grade resin in horticultural applications are starting to get attention in the green slope, dust storms have been applied in other areas of governance.
However, PLA's extrusion process is not easy, is only suitable in some advanced PET extrusion molding machine for processing, and the thickness of the extruded sheet only in the range of 0.2-1.0mm. Process of moisture content and are particularly sensitive to the processing temperature, buffered lactic acid, generally requires its moisture content is less than 50PPM, this equipment drying system and temperature control system also proposed new requirements. Processing, if no suitable crystallization apparatus, the recovery of scrap is also a major problem, which is on the market a large number of scrap in circulation causes PLA.
However, PLA's extrusion process is not easy, is only suitable in some advanced PET extrusion molding machine for processing, and the thickness of the extruded sheet only in the range of 0.2-1.0mm. Process of moisture content and are particularly sensitive to the processing temperature, buffered lactic acid, generally requires its moisture content is less than 50PPM, this equipment drying system and temperature control system also proposed new requirements. Processing, if no suitable crystallization apparatus, the recovery of scrap is also a major problem, which is on the market a large number of scrap in circulation causes PLA.
polylactide latest patent
BRUSSELS BIOTECH (BE) 2004 年 2 月 13 Publication Date of World Patent WO 2004 014889, reported polylactic acid, its independence items include the following: ⑴ lactic acid was prepared as follows: (a) evaporation of lactic acid or lactic acid derivatives a molecular weight of 400-2000 solution preparation, the total acidity of lactic acid equivalent 119-124.5%, optical purity equal to 90-100% buffered lactic acid oligomers; (b) the oligomer depolymerization catalyst is added to the depolymerization reaction is prepared to give a lactic acid-rich gas phase and a liquid phase rich in oligomers; (c) condensing vapor to obtain a liquid crude acid; (d) extracting the crude acid crystals; (e) separation and to obtain a rich exhaust crystals lactic acid crystals wet cake; (f) drying the wet cake to obtain pre-purification of lactic acid; and (g) pre-purification of lactic acid obtained crystalline residue acidity than 10meq/kg, the water content of less than 200ppm and meso-lactic acid content of less than 1% purification of lactic acid; ⑵ polymer obtained above polylactic acid was obtained.
2004 BOTELHO T and other published patent WO 2004 057008-A1, reported a confectionery packaging material for preparation of the polylactic acid is mainly obtained by the fermentation method, examples of specific methods reported as follows: the culture medium ( 451) (including whey, milk protein and other nutrients, such as salts and cysteine) and heated to 70 ℃ for 45 minutes and then cooled to 45 ℃. Adding Lactobacillus helveticus (9 g) and Flavourzyme (RTM) (A) (26.5 g). Batch fermentation 9 hours,potassium lactate, lactose and Flavourzyme (RTM) of fresh broth. PH was adjusted to 5.75 with ammonia gas, bio-density control at 7-8%, the fermentation process continuous aeration, aeration rate of 1 liter / min. During the 34 days of fermentation period dilution rate 0.15-0.3 / hour. Lactate solution in the effluent of 4% dilution rate of 0.3 / h under the yield was 12 g / liter. Hour. Lactic acid effluent and a chelating ion exchange resin separation and then after two successive electrodialysis recovery of 85-90%.
HANZSCH BERND other August 21, 2003 U.S. Patent US 2003 158360, reported a method for preparing polylactic acid, the following steps: fermentation of starch obtained produce lactic acid, by ultrafiltration, nano filtration and / or electrodialysis ultrapure zinc lactate, concentrated acid, to prepare the prepolymer, the ring is double resolve polylactic acid, lactic acid purification double, double ring-opening and deprotection monomeric lactic acid polymer obtained polylactic acid.SHIMADZU CORP 2002 年 10 月 15 Publication Date of JP 2002 300898, reported a production of lactic acid and polylactic acid. Specific methods: ⑴ synthesis using ammonium lactate lactate; ⑵ butyltin outside in addition to the presence of a catalyst, the polycondensation of lactic acid ester, an average molecular weight less than 15000mol.wt synthesis of polylactic acid (lactic acid prepolymer); ⑶ solution obtained copolymerized lactic acid; The method further comprises ring-opening polymers polylactic acid.
SHIMADZU CORP, OHARA H, TOYOTA JIDOSHA KK, ITO M and SAWA S 2002 年 8 月 8 Publication Date Patent WO 2002 60891-A, reported for the production of biodegradable plastics, and polylactic acid preparation method of the patent One embodiment of the method reported as follows: fermentation of L-ammonium lactate and ethanol at 90-100 ℃ the reaction, separation, collection of alcohol; 120 ℃ the removal reaction of the water; obtained was purified by distillation of ethyl lactate In dioctyltin 160 ℃ polycondensation in the presence of ethyl lactate and ethanol off. The resulting reaction solution was distilled at 200 ℃ acid obtained in a yield of 99.2%. In the polymerization in the presence of lactic acid dioctyltin of lactic acid. NATL INST OF ADVANCED INDUSTRIAL SCIENCE TECHNOLOGY METI, KONAN KAKO KK and TOKIWA YUTAKA2001 August 21, disclosed in Japanese Patent JP 2001 224392, reported the use of enzymes instead of the organic metal catalyst polylactic acid.
2004 BOTELHO T and other published patent WO 2004 057008-A1, reported a confectionery packaging material for preparation of the polylactic acid is mainly obtained by the fermentation method, examples of specific methods reported as follows: the culture medium ( 451) (including whey, milk protein and other nutrients, such as salts and cysteine) and heated to 70 ℃ for 45 minutes and then cooled to 45 ℃. Adding Lactobacillus helveticus (9 g) and Flavourzyme (RTM) (A) (26.5 g). Batch fermentation 9 hours,potassium lactate, lactose and Flavourzyme (RTM) of fresh broth. PH was adjusted to 5.75 with ammonia gas, bio-density control at 7-8%, the fermentation process continuous aeration, aeration rate of 1 liter / min. During the 34 days of fermentation period dilution rate 0.15-0.3 / hour. Lactate solution in the effluent of 4% dilution rate of 0.3 / h under the yield was 12 g / liter. Hour. Lactic acid effluent and a chelating ion exchange resin separation and then after two successive electrodialysis recovery of 85-90%.
HANZSCH BERND other August 21, 2003 U.S. Patent US 2003 158360, reported a method for preparing polylactic acid, the following steps: fermentation of starch obtained produce lactic acid, by ultrafiltration, nano filtration and / or electrodialysis ultrapure zinc lactate, concentrated acid, to prepare the prepolymer, the ring is double resolve polylactic acid, lactic acid purification double, double ring-opening and deprotection monomeric lactic acid polymer obtained polylactic acid.SHIMADZU CORP 2002 年 10 月 15 Publication Date of JP 2002 300898, reported a production of lactic acid and polylactic acid. Specific methods: ⑴ synthesis using ammonium lactate lactate; ⑵ butyltin outside in addition to the presence of a catalyst, the polycondensation of lactic acid ester, an average molecular weight less than 15000mol.wt synthesis of polylactic acid (lactic acid prepolymer); ⑶ solution obtained copolymerized lactic acid; The method further comprises ring-opening polymers polylactic acid.
SHIMADZU CORP, OHARA H, TOYOTA JIDOSHA KK, ITO M and SAWA S 2002 年 8 月 8 Publication Date Patent WO 2002 60891-A, reported for the production of biodegradable plastics, and polylactic acid preparation method of the patent One embodiment of the method reported as follows: fermentation of L-ammonium lactate and ethanol at 90-100 ℃ the reaction, separation, collection of alcohol; 120 ℃ the removal reaction of the water; obtained was purified by distillation of ethyl lactate In dioctyltin 160 ℃ polycondensation in the presence of ethyl lactate and ethanol off. The resulting reaction solution was distilled at 200 ℃ acid obtained in a yield of 99.2%. In the polymerization in the presence of lactic acid dioctyltin of lactic acid. NATL INST OF ADVANCED INDUSTRIAL SCIENCE TECHNOLOGY METI, KONAN KAKO KK and TOKIWA YUTAKA2001 August 21, disclosed in Japanese Patent JP 2001 224392, reported the use of enzymes instead of the organic metal catalyst polylactic acid.
polylactic acid lactic acid method
⑴ direct polycondensation
Polycondensation is to direct condensation of lactic acid monomer, also called polymerization step. The presence of a dehydrating agent, lactic acid molecules in the hydroxyl and carboxyl groups heat dehydration, direct polycondensation oligomers. Adding a catalyst, lactic acid powder, low molecular weight polylactic acid polymer with a higher molecular weight of polylactic acid.
⑵ two-step
The cyclic dimer of lactic acid lactide, and then into a ring-opening polycondensation polylactic acid. This technology is more mature, the U.S. company NatureWorks polylactic acid production process is the process technology. China Sea being developed jointly with the Chinese Academy of polylactic acid production technology calcium lactate, the main process raw materials by microbial fermentation of lactic acid, and then after purification, dehydration oligomeric, pyrolysis, and finally aggregated into polylactic acid.
⑶ reactive extrusion prepare high molecular weight polylactic acid
A batch-type stirred reactor and a twin-screw extruder combined continuous melt polymerization experiments, obtained from a lactic acid obtained by the continuous melt-polycondensation of the molecular weight of polylactic acid 150000. Twin-screw extruder of the low molar mass of lactic acid prepolymer further condensation in an extruder to prepare a high molar mass of the polylactic acid. The reaction temperature is 150 ℃, the amount of catalyst was 0.5%, a screw speed of 75 r / min when the double-screw extruder polycondensation reaction rapidly and effectively increase the molar mass of the polylactic acid, and the reaction product was dispersed reduced coefficient of extrusion, uniformity better. The DSC curve by comparison, obtained by reactive extrusion of the polylactic acid polycondensation process crystallinity decreased, polylactic acid material which is to improve the performance in the course of a greater brittleness is beneficial.
Polycondensation is to direct condensation of lactic acid monomer, also called polymerization step. The presence of a dehydrating agent, lactic acid molecules in the hydroxyl and carboxyl groups heat dehydration, direct polycondensation oligomers. Adding a catalyst, lactic acid powder, low molecular weight polylactic acid polymer with a higher molecular weight of polylactic acid.
⑵ two-step
The cyclic dimer of lactic acid lactide, and then into a ring-opening polycondensation polylactic acid. This technology is more mature, the U.S. company NatureWorks polylactic acid production process is the process technology. China Sea being developed jointly with the Chinese Academy of polylactic acid production technology calcium lactate, the main process raw materials by microbial fermentation of lactic acid, and then after purification, dehydration oligomeric, pyrolysis, and finally aggregated into polylactic acid.
⑶ reactive extrusion prepare high molecular weight polylactic acid
A batch-type stirred reactor and a twin-screw extruder combined continuous melt polymerization experiments, obtained from a lactic acid obtained by the continuous melt-polycondensation of the molecular weight of polylactic acid 150000. Twin-screw extruder of the low molar mass of lactic acid prepolymer further condensation in an extruder to prepare a high molar mass of the polylactic acid. The reaction temperature is 150 ℃, the amount of catalyst was 0.5%, a screw speed of 75 r / min when the double-screw extruder polycondensation reaction rapidly and effectively increase the molar mass of the polylactic acid, and the reaction product was dispersed reduced coefficient of extrusion, uniformity better. The DSC curve by comparison, obtained by reactive extrusion of the polylactic acid polycondensation process crystallinity decreased, polylactic acid material which is to improve the performance in the course of a greater brittleness is beneficial.
The major advantages of polylactic acid has the following aspects
⑴ polylactic acid (PLA) is a novel biodegradable material, the use of renewable resources (such as corn) starch raw material proposed. Starch material made of lactic acid by the fermentation process, and then converted by chemical synthesis of polylactic acid. It has good biodegradability after use can be completely degraded by microorganisms magnessium lactate, and ultimately generate carbon dioxide and water, do not pollute the environment, which is very favorable to the protection of the environment, is recognized as an environmentally friendly material. Caring for the earth, you and I have a responsibility. World carbon dioxide emissions in 2030, according to news reports global temperature will rise to 60 ℃, ordinary plastic processing method is still burning cremation, causing a lot of greenhouse gases into the air, and polylactic acid plastic is buried in the soil degradation, resulting in carbon dioxide directly into the soil organic matter or plant uptake, do not go into the air, will not cause the greenhouse effect.
⑵ good mechanical and physical properties. Polylactic acid suitable for blow molding, thermoplastic and other processing methods, processing convenience, is widely used. Can be used for processing from industry to civilian various plastic products, packaged food, fast food boxes, non-woven, industrial and civilian cloth. Further processed into agricultural fabric, fabric care, wipes, hygiene products, outdoor anti-UV fabric, Ethyl lactate, mats surface, etc., the market is very promising.
⑶ compatibility and good biodegradable. Polylactic acid in the medical field is also widely used, such as to produce disposable infusion equipment, free split-type surgical sutures and other low molecular weight polylactic acid packaging for drug delivery agent.
⑷ polylactic acid (PLA) biodegradable plastics in addition to the basic features, but also has its own unique features. Traditional biodegradable plastic strength, transparency and resistance to climate change are not as good as ordinary plastic.
⑸ polylactic acid (PLA) plastics and petrochemical synthesis similar basic physical properties, ie it can be widely used to manufacture a variety of applications. Polylactic acid also has good gloss and transparency, and the use of polystyrene plastic film rather, is the other biodegradable products can not provide.
⑹ polylactic acid (PLA) with the most good tensile strength and elongation, polylactic acid can produce a variety of common processing methods, such as: melt extrusion molding, injection molding, blown film molding, foam molding, and vacuum forming, and widely used polymers have similar molding conditions, in addition it also has the same conventional film printing performance. So, polylactic acid can be the different needs of the industry to produce a wide range of applications.
⑺ polylactic acid (PLA) film has good air permeability, oxygen permeability, and two-carbon dioxide permeability resistance, it also has a characteristic odor isolation. Viruses and fungi easily attached to the surface of biodegradable plastic, so it is safe and hygienic concerns, however, polylactic acid is the only excellent antibacterial and antifungal properties of biodegradable plastics.
When incineration ⑻ polylactic acid (PLA), the heat of combustion of the burning of the same paper, incineration conventional plastic (such as polyethylene) in half, and incineration of the polylactic acid will not release nitrides, sulfides and other toxic gases. The body also contains lactic acid monomer present in the form, which means that products of this decomposition have security.
⑵ good mechanical and physical properties. Polylactic acid suitable for blow molding, thermoplastic and other processing methods, processing convenience, is widely used. Can be used for processing from industry to civilian various plastic products, packaged food, fast food boxes, non-woven, industrial and civilian cloth. Further processed into agricultural fabric, fabric care, wipes, hygiene products, outdoor anti-UV fabric, Ethyl lactate, mats surface, etc., the market is very promising.
⑶ compatibility and good biodegradable. Polylactic acid in the medical field is also widely used, such as to produce disposable infusion equipment, free split-type surgical sutures and other low molecular weight polylactic acid packaging for drug delivery agent.
⑷ polylactic acid (PLA) biodegradable plastics in addition to the basic features, but also has its own unique features. Traditional biodegradable plastic strength, transparency and resistance to climate change are not as good as ordinary plastic.
⑸ polylactic acid (PLA) plastics and petrochemical synthesis similar basic physical properties, ie it can be widely used to manufacture a variety of applications. Polylactic acid also has good gloss and transparency, and the use of polystyrene plastic film rather, is the other biodegradable products can not provide.
⑹ polylactic acid (PLA) with the most good tensile strength and elongation, polylactic acid can produce a variety of common processing methods, such as: melt extrusion molding, injection molding, blown film molding, foam molding, and vacuum forming, and widely used polymers have similar molding conditions, in addition it also has the same conventional film printing performance. So, polylactic acid can be the different needs of the industry to produce a wide range of applications.
⑺ polylactic acid (PLA) film has good air permeability, oxygen permeability, and two-carbon dioxide permeability resistance, it also has a characteristic odor isolation. Viruses and fungi easily attached to the surface of biodegradable plastic, so it is safe and hygienic concerns, however, polylactic acid is the only excellent antibacterial and antifungal properties of biodegradable plastics.
When incineration ⑻ polylactic acid (PLA), the heat of combustion of the burning of the same paper, incineration conventional plastic (such as polyethylene) in half, and incineration of the polylactic acid will not release nitrides, sulfides and other toxic gases. The body also contains lactic acid monomer present in the form, which means that products of this decomposition have security.
polylactic acid
A single acid molecule has a hydroxyl group and a carboxyl group, a plurality of lactic acid molecules together,magnessium lactate other molecules dehydration condensation,-COOH and-OH in the other molecule dehydration condensation, so that they form a hand in hand a polymer called polylactic acid. Polylactic acid is also known as polylactide, are polyester family. Polylactic acid as the main raw material is a polymer obtained by polymerizing, adequate sources of raw materials and can be recycled. Polylactic acid production process without pollution, and biodegradable products, to achieve the cycle in nature and is therefore ideal green polymer materials.
Polylactic acid (H-[OCHCH3CO] n-OH) good thermal stability, processing temperature 170 ~ 230 ℃, good solvent resistance, can be processed in various ways, such as extrusion, spinning, Calcium lactate , injection blow molding. Products made from poly lactic acid in addition to biodegradation, biocompatibility, gloss, transparency, texture, and good heat resistance, the development of polylactic BrightChina acid (PLA) also have some antibacterial, flame resistance and UV resistance, so the wide range of uses, can be used as packaging materials, fibers and nonwoven materials, mainly used for clothing (underwear, outerwear), industry (construction, agriculture, forestry, paper) and health and other fields.
Polylactic acid (H-[OCHCH3CO] n-OH) good thermal stability, processing temperature 170 ~ 230 ℃, good solvent resistance, can be processed in various ways, such as extrusion, spinning, Calcium lactate , injection blow molding. Products made from poly lactic acid in addition to biodegradation, biocompatibility, gloss, transparency, texture, and good heat resistance, the development of polylactic BrightChina acid (PLA) also have some antibacterial, flame resistance and UV resistance, so the wide range of uses, can be used as packaging materials, fibers and nonwoven materials, mainly used for clothing (underwear, outerwear), industry (construction, agriculture, forestry, paper) and health and other fields.
lactobacillus tablets and side effects
Lactobacillus tablets in recent years developed a digestive non-prescription drugs, the main ingredient is lactobacillus, accessories magnesium stearate, starch, sucrose,potassium lactate, cocoa powder, protein, sugar, talc.
Produced by the lactic acid bacteria lactobacillus with the activity of a polypeptide or protein, can promote the growth of intestinal bacteria, kill bacteria and promote gastric Sodium lactate, enhance digestion, commonly used in indigestion, enteritis and diarrhea in children embolism.
Lactobacillus tablets found no toxic side effects, just follow the instructions to take, it will not produce side effects. But for lactose, galactose and dairy allergy.
Produced by the lactic acid bacteria lactobacillus with the activity of a polypeptide or protein, can promote the growth of intestinal bacteria, kill bacteria and promote gastric Sodium lactate, enhance digestion, commonly used in indigestion, enteritis and diarrhea in children embolism.
Lactobacillus tablets found no toxic side effects, just follow the instructions to take, it will not produce side effects. But for lactose, galactose and dairy allergy.
lactobacillus tablets precautions and drug interactions
1. The Drug Hypersensitivity, magnessium lactate. 2 If overdose or serious adverse reactions should seek medical care immediately. 3. The drug prohibition of the use of property changes. 4 Make the medicine where children can not reach. 5 Children must be under adult supervision. 6 If you are using other drugs, the use of the drug before you consult a physician or pharmacist.
Drug Interactions1 bismuth, buffered lactic acid, medicinal charcoal, tinctures, etc. can absorb the drug should not be shared. 2 used simultaneously with other drugs may occur drug interactions, please consult your physician or pharmacist. The drug in the intestine to form a protective layer to prevent pathogens, viruses; stimulates intestinal secretion of antibodies, increased intestinal immunity; selectively kill intestinal bacteria, protecting promote the growth of beneficial bacteria; regulating intestinal electrolyte, water balance; promote gastric secretion, enhance digestive function.
Drug Interactions1 bismuth, buffered lactic acid, medicinal charcoal, tinctures, etc. can absorb the drug should not be shared. 2 used simultaneously with other drugs may occur drug interactions, please consult your physician or pharmacist. The drug in the intestine to form a protective layer to prevent pathogens, viruses; stimulates intestinal secretion of antibodies, increased intestinal immunity; selectively kill intestinal bacteria, protecting promote the growth of beneficial bacteria; regulating intestinal electrolyte, water balance; promote gastric secretion, enhance digestive function.
lactobacillus tablets use
Lactobacillus tablets should not be combined with antibiotics, some people suffer from abdominal pain, bloating or gastrointestinal discomfort, and often prefer this drug with gentamicin, norfloxacin (norfloxacin) and potassium lactate taken together, that can be adjusted so that both gastrointestinal function, and can be sterilized, it will enhance the therapeutic effect. In fact, lactobacillus tablets can not be combined with antibiotics for. Because lactobacillus are biologically active substances, antibiotics inhibit or reduce its biological activity, reduce the efficacy of the drug. In addition to these drugs, sulfonamides, lactic acid powder, nor with the drug combination. If the drug really necessary in the use of the process in combination with other drugs, you need to consult a doctor, so as not to affect the efficacy. Third, lactobacillus tablets should not be with a convergence effect of the drug combination when people got diarrhea enteritis or improper diet, often would lactobacillus tablets with tannic acid protein, bismuth carbonate, medicinal charcoal, grease, etc. Compound Fenno drug combination . These drugs are adsorbed or convergence effect, can prevent intestinal abnormal fermentation (ie, protein in the intestine corruption, induced a large number of pathogenic bacteria to grow), to reduce the absorption of toxins in the intestine and the intestinal mucous membrane irritation, reduce leakage , and thus play antidiarrheal effect. However, these drugs adsorption and convergence, will reduce the activity of lactic acid bacteria, so if the lactobacillus tablets in combination with these drugs but will reduce its efficacy. In addition, Juefu lactobacillus tablets after, to use warm water in the mouth of residual drug paste, water temperature not exceeding 40 degrees Celsius better. At this point, we must pay attention to the water temperature is not too high, because the water temperature is too high is easy to suppress the activity of lactic acid bacteria and reduce efficacy.
lactobacillus tablets
Lactobacillus tablets, developed in recent years to digest non-prescription drugs, commonly used in indigestion,ferrous lactate, the treatment of children with diarrhea and other illnesses. Its pharmacological effects are: ① in the intestinal wall can be formed on the surface protective layer, effectively blocking pathogens and viruses; ② can stimulate the intestinal tract to produce antibodies, thereby improving their intestinal immune function; ③ able to protect and promote the intestine growth of beneficial bacteria that selectively kills the pathogen; ④ can regulate intestinal water and electrolyte balance; ⑤ can promote gastric acid secretion, buffered lactic acid. When using lactobacillus films, should be strictly in accordance with the right approach to take, if unauthorized changes taking method, it will weaken the efficacy. So, taking lactobacillus films, should pay attention to what matters it? First, lactobacillus tablets to chew some people feel Juefu drug smells bad, it is direct water delivery service. In fact, doing so on the efficacy of the play is very unfavorable. Because lactobacillus tablets in the mouth when chewed saliva sufficiently mixed to form a paste, which makes the drug into the gastrointestinal tract to the rapid decomposition, directly enhance the acidity of the intestines, which can inhibit the propagation of intestinal pathogens . Moreover, the fermentation of lactic acid can be reduced saliva and gas effects play a role in the drug speed.
D-lactic acid in the polylactic acid biodegradable material application
Lactic acid is polylactic acid bioplastics (polylactide, PLA) ferrous lactate. Poly (lactic acid) depends on the physical properties of D, L two isomers composition and content. The racemic D, Ethyl lactate synthesized racemic D, L-polylactic acid (PDLLA) is amorphous structure, poor mechanical properties, degradation time is shorter, and the contraction occurs in the body, the contraction rate of 50 % or more, the application has been limited. L-polylactic acid (PLLA) and D-polylactic acid (PDLA) regular arrangement of the segment, crystallinity, mechanical strength and melting point so far over PDLLA.
2013年7月23日星期二
D-lactic acid derivative of the application in the chemical industry
D-lactic acid as a raw material with a ferrous lactate esters of perfume, synthetic resin coatings, adhesives and printing ink applications such as the production of widely used in the electronics industry, oil pipelines and cleaning also has applications. Sodium lactate, D-methyl lactate with water and a variety of polar solvents were uniformly mixed to fully dissolve nitrocellulose, cellulose acetate, cellulose acetobutyrate, and a variety of polar synthetic polymers, both having a melting point high, the advantages of slow evaporation, is an excellent high boiling solvent, a mixed solvent may be used as a component to improve the workability and solubilization, in addition, also be used as medicine, pesticide materials and other chiral precursor synthesis , intermediates.
D-lactic acid in chiral synthesis
D-Lactic acid with high optical purity (97%) as a chiral center is a variety of chiral substance precursor, is an important intermediate of organic synthesis, chiral raw material, widely used in pharmaceutical, efficiency and low toxicity pesticides and herbicides , cosmetics and other fields chiral synthesis. For example, Japanese Tatari use of Daicel Chemical Industries, Inc. D-lactic acid manufacturing quality herbicides Puma (Puma Super).
Germany Hoeehst company also developed the buffered lactic acid as the raw material of new efficient herbicide SHINING (Whip Super).
German company BASF to D-lactic acid isopropyl ester as raw materials to produce herbicide Duplosan, and has mass market.
In addition, calcium antagonists antihypertensive drugs, picolinic acid derivatives and MCPA acid, fluorine-based herbicides, also with high optical purity D-lactic acid as a raw material.
Germany Hoeehst company also developed the buffered lactic acid as the raw material of new efficient herbicide SHINING (Whip Super).
German company BASF to D-lactic acid isopropyl ester as raw materials to produce herbicide Duplosan, and has mass market.
In addition, calcium antagonists antihypertensive drugs, picolinic acid derivatives and MCPA acid, fluorine-based herbicides, also with high optical purity D-lactic acid as a raw material.
D-lactic acid structure and physicochemical properties
The scientific name of lactic acid α-hydroxy acid, formula C2H5OCOOH, is a naturally occurring calcium lactate, is widely present in the human body, animals, plants and microbes.
Lactic acid is the smallest natural chiral molecules carboxyl group in α-carbon atom is an asymmetric carbon atom, with L (+) and D (-)-isomers. L-lactic acid is D-type, D-lactic acid is L-type, L-lactic acid and D-lactic acid is the ratio of the racemic mixture of DL-type. D-lactic acid and L-lactic acid in addition to the optically active, the other physical properties are the same as [2], but the physical properties of DL-type vary with them, and in its melting point and heat of fusion than a single D-or L-configuration of low.
D-lactic acid with a magnessium lactate typical chemical properties of a weak acid solution, the concentration of more than 50% portion is formed when milk anhydride, the reaction of alcohols with some alkyd resin, the heating conditions can be intermolecular esterification , to form lactic acid lactylate (C6H10O5), heating may be further diluted and hydrolyzed to D-lactic acid. Role of zinc oxide in the dehydrating agent, the removal of two molecules of two
molecules of D-lactic acid in water, to form a cyclic dimer from poly D-lactide (C6H8O4, DLA). Sufficiently dehydrated D-lactic acid polymer can be formed. The more concentrated the acid esterification stronger the trend itself, thus lactic acid and lactic acid is typically a mixture of lactide.
Lactic acid is the smallest natural chiral molecules carboxyl group in α-carbon atom is an asymmetric carbon atom, with L (+) and D (-)-isomers. L-lactic acid is D-type, D-lactic acid is L-type, L-lactic acid and D-lactic acid is the ratio of the racemic mixture of DL-type. D-lactic acid and L-lactic acid in addition to the optically active, the other physical properties are the same as [2], but the physical properties of DL-type vary with them, and in its melting point and heat of fusion than a single D-or L-configuration of low.
D-lactic acid with a magnessium lactate typical chemical properties of a weak acid solution, the concentration of more than 50% portion is formed when milk anhydride, the reaction of alcohols with some alkyd resin, the heating conditions can be intermolecular esterification , to form lactic acid lactylate (C6H10O5), heating may be further diluted and hydrolyzed to D-lactic acid. Role of zinc oxide in the dehydrating agent, the removal of two molecules of two
molecules of D-lactic acid in water, to form a cyclic dimer from poly D-lactide (C6H8O4, DLA). Sufficiently dehydrated D-lactic acid polymer can be formed. The more concentrated the acid esterification stronger the trend itself, thus lactic acid and lactic acid is typically a mixture of lactide.
The structure of lactic acid
Lactic acid structural formula CH3CHOHCOOH, molecular formula C3H6O3, relative molecular mass of 90.08, both molecules with hydroxyl (OH) and a carboxyl group (COOH) two functional groups, is the most widely used naturally occurring hydroxy carboxylic acid, is the most simple one kinds of zinc lactate. Acid widely found in animals, plants and microorganisms, the presence of human and animal body tissue metabolism of L-lactic acid and L-lactic acid to L-lactate dehydrogenase, D-lactic acid dehydrogenase is not present.Ethyl lactate lactic acid is easily absorbed directly participate in the metabolism, promote digestion, known as "muscle lactic acid" is bio-chemical, fine chemical industry in a twinkling star. Human intake of L-lactic acid, can be absorbed and decomposed, while the D lactic acid can not decompose easily in vivo formation of D-lactic acid accumulation.
Now widely used in pharmaceutical, wine, food, beverage, health care products, paper, leather, tobacco, paint, ink, electroplating and plastics industry and pipeline corrosion, daily chemical and other fields.
Now widely used in pharmaceutical, wine, food, beverage, health care products, paper, leather, tobacco, paint, ink, electroplating and plastics industry and pipeline corrosion, daily chemical and other fields.
the use of lactic acid in the agricultural sector
1, more than 99% optical purity of lactic acid, the pesticides used in the production release of magnessium lactate, such as herbicides, with non-toxic to crops and soil characteristics and efficient; lactic acid polymer used in the production of agricultural films, which can be used replace the plastic film, can be bacterial decomposition allows the soil to absorb, environmentally friendly; lactic acid is also used for green fodder storage agent, forage maturation agent.
2, in the swine and poultry feed as growth promoters. Calcium lactate can reduce the PH value of the stomach, digestive enzymes play activated, the role of improving the acid digestion, and the growth of beneficial intestinal epithelium. Piglets after weaning feed containing acidifier few weeks to feed their weaning period can be increased by 15% in weight;
3, lactic acid inhibit microbial growth, lactating piglets will be infected by the disease caused by E. coli and Salmonella in feed by adding lactic acid can prevent the pig gastrointestinal tract pathogen growth under; lactic acid can be used as feed preservatives and improve feed , cereals and meat by-products processed products microbial stabilizer drinking water in poultry and pig adding lactic acid, can effectively inhibit the growth of pathogenic bacteria, animal weight gain speed.
2, in the swine and poultry feed as growth promoters. Calcium lactate can reduce the PH value of the stomach, digestive enzymes play activated, the role of improving the acid digestion, and the growth of beneficial intestinal epithelium. Piglets after weaning feed containing acidifier few weeks to feed their weaning period can be increased by 15% in weight;
3, lactic acid inhibit microbial growth, lactating piglets will be infected by the disease caused by E. coli and Salmonella in feed by adding lactic acid can prevent the pig gastrointestinal tract pathogen growth under; lactic acid can be used as feed preservatives and improve feed , cereals and meat by-products processed products microbial stabilizer drinking water in poultry and pig adding lactic acid, can effectively inhibit the growth of pathogenic bacteria, animal weight gain speed.
the use of lactic acid in the beauty industry
1, due to lactic acid powder is the skin's natural moisturizing factor inherent part of many skin care products are widely used as a moisturizing agent. L-lactic acid is the most effective one AHA and little irritation;
2, the L-lactic acid naturally present in the hair, the role of the shiny surface of the hair, often as a variety of hair care products ferrous lactate pH adjusting agent; lactic acid can be used as a humectant in various bath wash items such as bath liquid , bar soaps and moisturizers honey. The liquid soap, shampoo and soap can be used as a pH adjusting agent. In addition, lactic acid added to the bar soap can reduce the loss of water during storage, thus preventing the soap dry.
2, the L-lactic acid naturally present in the hair, the role of the shiny surface of the hair, often as a variety of hair care products ferrous lactate pH adjusting agent; lactic acid can be used as a humectant in various bath wash items such as bath liquid , bar soaps and moisturizers honey. The liquid soap, shampoo and soap can be used as a pH adjusting agent. In addition, lactic acid added to the bar soap can reduce the loss of water during storage, thus preventing the soap dry.
use of lactic acid in the industrial sector
1, the lactic acid in the fermentation industry for controlling the pH and increase the purity of the fermentation. Sodium lactate can neutralize nicotine nicotine, reducing harmful ingredients to improve the quality of tobacco. In the textile industry for processing fibers, the fibers can be easily pigmented increase gloss, so soft touch. Ink in the paint industry as a pH adjusting agent and synthetic agents; in biodegradable plastic fiber industry is new material polylactic acid PLA raw material of choice.
2, the polylactic acid may be used as a starting material, in the leather industry, the removal of magnessium lactate and calcium lime leather, the leather soft and fine, thereby producing high-quality leather; acid nickel as the network has a unique constants, is often used in nickel plating process, it also can be used as plating tank in pH buffers and stabilizers. Acid as pH adjusting agents and synthetic agents can be used in various water-based coating adhesion system. Such as the role of lactic acid has a cleansing detergent for washing cleaning products than traditional organic detergents better performance, so it can be used in many cleaning products.
2, the polylactic acid may be used as a starting material, in the leather industry, the removal of magnessium lactate and calcium lime leather, the leather soft and fine, thereby producing high-quality leather; acid nickel as the network has a unique constants, is often used in nickel plating process, it also can be used as plating tank in pH buffers and stabilizers. Acid as pH adjusting agents and synthetic agents can be used in various water-based coating adhesion system. Such as the role of lactic acid has a cleansing detergent for washing cleaning products than traditional organic detergents better performance, so it can be used in many cleaning products.
Use of lactic acid in the pharmaceutical industry
1, in the wards, operating rooms, laboratories and other places in steam sterilization using buffered lactic acid, can effectively kill bacteria in the air, decrease the disease, to improve health purposes; widely used as preservatives in medicine, the carrier agent, cosolvent, pharmaceutical preparation, pH adjusting agent;
2,Zinc lactate polymer to obtain a polylactic acid, polyglycolic acid can be pumped into a spun into line, this line is good surgical sutures, seam healing without stitches, degrade into lactic acid can be automatically absorbed by the body, without adverse consequences.
2,Zinc lactate polymer to obtain a polylactic acid, polyglycolic acid can be pumped into a spun into line, this line is good surgical sutures, seam healing without stitches, degrade into lactic acid can be automatically absorbed by the body, without adverse consequences.
the use of lactic acid in the food industry
1, lactic acid has a strong preservative effect, can be used in wine, beverage, meat, food, pastry, vegetables (olives, cucumbers, pearl onions) marinated and canning, food processing, fruit storage, with the regulation pH, antibacterial, extend shelf life, seasoning, buffered lactic acid, improve product quality and so on.
2, seasoning, the lactic acid acidity increase unique delicious food in salad, soy sauce,Ethyl lactate, spices adding a certain amount of lactic acid, can maintain the stability of the microbial product, security, while the more moderate taste ; the mild acidity of lactic acid medium, but also as careful deployment of soft drinks and juices preferred acidifying agent.
2, seasoning, the lactic acid acidity increase unique delicious food in salad, soy sauce,Ethyl lactate, spices adding a certain amount of lactic acid, can maintain the stability of the microbial product, security, while the more moderate taste ; the mild acidity of lactic acid medium, but also as careful deployment of soft drinks and juices preferred acidifying agent.
Lactic acid - Preparation
Fermentation
Fermentation of sugar is the main way of ferrous lactate bacteria, adjust the pH value of about 5, for about 50 or 60dm; C Fermentation three to five days to give the crude acid. Fermentation of raw materials generally corn, rice, sweet potato starch material, alfalfa, cellulose and the like as raw material, the lactic acid fermentation stage to lactic acid production lot, but the acid does not have much higher quality, mainly Rhizopus and other strains of Lactobacillus. The fermentation of different strains of different ways, can be divided into the same type of fermentation and shaped fermentation, the actual presence of microorganisms as other physiological activities, may not be simply a certain kind of fermentation pathway. Sodium lactate the same type of fermentation and shaped fermentation.
Synthesis
Lactonitrile law: Lactonitrile method is to acetaldehyde and hydrogen cyanide cold milk continuously fed to the reactor to generate a nitrile (or directly with the milk as raw material nitrile), with a pump into the milk nitrile hydrolysis reactor, into sulfuric acid and water, the milk nitrilase crude lactic acid. And then give it away crude lactic acid esterification reactor, adding ethanol esterification, distillation, concentration, lactic acid decomposition was fine. American Sterling Chemical Company and Japan Musashino Chemical companies are adopting this synthesis of lactic acid.
Acrylonitrile law: acrylonitrile and acrylonitrile method is hydrolyzed in sulfuric acid fed to the reactor, and then hydrolysis reactor anyone to esterification reaction with methanol; then after separation of the hydrogen sulfate, the crude ester distillation column , the bottom was fine ester; then refined into a second distillation column ester, thermal decomposition, bottom too thin lactic acid, concentrated by vacuum to obtain the product.
Propionic acid method: method propionic acid as raw materials, through chlorination, hydrolysis of the crude lactic acid powder; re-esterification, distillation, hydrolysis products. This method is more expensive raw materials, only a few companies such as Japan's road contest manufacturers to adopt. Reaction is as follows:
CH3CH2COOH Cl2 one → CH3CHClCOOH NaOH-→ CH3CH (OH) COOH NaCl
Enzymatic method
Chlorine acid enzymatic conversion: the use of the purified L-2-halo acid dehalogenase and DL-2-halo acid dehalogenase were acting on the substrate L-2-chloro-propionic acid and DL-2-chloro- acid, L-lactic acid obtained bittern off or D-lactic acid. L-2-halo acid dehalogenase catalyzed L-2-chloropropionic acid, and DL-2-halo acid dehalogenase catalyzed both L-2-chloropropionic acid, but also the catalytic L-2-chloropropyl generate the corresponding optically active acid, catalytic conversion simultaneous configuration. Enzymatic conversion of pyruvate: highest activity of lactate dehydrogenase from the chaos DSM20196 Lactobacillus cells obtained in D-lactic acid dehydrogenase, a non-optically active pyruvate as substrate D-lactic acid can be obtained.
Fermentation of sugar is the main way of ferrous lactate bacteria, adjust the pH value of about 5, for about 50 or 60dm; C Fermentation three to five days to give the crude acid. Fermentation of raw materials generally corn, rice, sweet potato starch material, alfalfa, cellulose and the like as raw material, the lactic acid fermentation stage to lactic acid production lot, but the acid does not have much higher quality, mainly Rhizopus and other strains of Lactobacillus. The fermentation of different strains of different ways, can be divided into the same type of fermentation and shaped fermentation, the actual presence of microorganisms as other physiological activities, may not be simply a certain kind of fermentation pathway. Sodium lactate the same type of fermentation and shaped fermentation.
Synthesis
Lactonitrile law: Lactonitrile method is to acetaldehyde and hydrogen cyanide cold milk continuously fed to the reactor to generate a nitrile (or directly with the milk as raw material nitrile), with a pump into the milk nitrile hydrolysis reactor, into sulfuric acid and water, the milk nitrilase crude lactic acid. And then give it away crude lactic acid esterification reactor, adding ethanol esterification, distillation, concentration, lactic acid decomposition was fine. American Sterling Chemical Company and Japan Musashino Chemical companies are adopting this synthesis of lactic acid.
Acrylonitrile law: acrylonitrile and acrylonitrile method is hydrolyzed in sulfuric acid fed to the reactor, and then hydrolysis reactor anyone to esterification reaction with methanol; then after separation of the hydrogen sulfate, the crude ester distillation column , the bottom was fine ester; then refined into a second distillation column ester, thermal decomposition, bottom too thin lactic acid, concentrated by vacuum to obtain the product.
Propionic acid method: method propionic acid as raw materials, through chlorination, hydrolysis of the crude lactic acid powder; re-esterification, distillation, hydrolysis products. This method is more expensive raw materials, only a few companies such as Japan's road contest manufacturers to adopt. Reaction is as follows:
CH3CH2COOH Cl2 one → CH3CHClCOOH NaOH-→ CH3CH (OH) COOH NaCl
Enzymatic method
Chlorine acid enzymatic conversion: the use of the purified L-2-halo acid dehalogenase and DL-2-halo acid dehalogenase were acting on the substrate L-2-chloro-propionic acid and DL-2-chloro- acid, L-lactic acid obtained bittern off or D-lactic acid. L-2-halo acid dehalogenase catalyzed L-2-chloropropionic acid, and DL-2-halo acid dehalogenase catalyzed both L-2-chloropropionic acid, but also the catalytic L-2-chloropropyl generate the corresponding optically active acid, catalytic conversion simultaneous configuration. Enzymatic conversion of pyruvate: highest activity of lactate dehydrogenase from the chaos DSM20196 Lactobacillus cells obtained in D-lactic acid dehydrogenase, a non-optically active pyruvate as substrate D-lactic acid can be obtained.
Lactic acid - main properties
1, moisture: with water, ethanol, glycerol miscible, acidic aqueous solution, PKa = 2.5. Insoluble in calcium lactate, carbon disulfide and petroleum ether. Heating under normal pressure, concentrated to 50%, the part becomes the lactic anhydride, product often contains 10% to 15% of the milk anhydride, as having a hydroxyl group and a carboxyl group, under certain conditions, the esterification reaction can occur, the product has three kind.
2 toxicity: rat oral LD50 for 3.73g/kg weight; ADI Unlimited regulations. Lactic acid has three isomers: DL-type, D-type and L-type. The rats were divided into three groups, each dosage dose of 1.7g/kg body weight of DL-type, D-type and potassium lactate, oral anatomy detected three hours later, DL-lactic acid can increase the liver glycogen , 40% to 95% within 3h absorption and transformation; D-and L-lactic acid in the blood lactate increased, there is excreted in the urine.
3, Biology: lactate dehydrogenase in the fermentation process pyruvate is converted to Calcium lactate. In general, the lactic acid metabolism and movement is generated continuously, but its concentration is generally not rise. Only in lactate production speed up the process, lactic acid can not be transported in a timely manner when the concentration will increase. Acid transport speed by a series of factors, including monocarboxylic transporter, lactate dehydrogenase concentration and isomeric forms, tissue oxidation. Generally the concentration of lactate in the blood is not in movement 1-2mmol / L, in the strong movement can rise to 20mmol / L.
2 toxicity: rat oral LD50 for 3.73g/kg weight; ADI Unlimited regulations. Lactic acid has three isomers: DL-type, D-type and L-type. The rats were divided into three groups, each dosage dose of 1.7g/kg body weight of DL-type, D-type and potassium lactate, oral anatomy detected three hours later, DL-lactic acid can increase the liver glycogen , 40% to 95% within 3h absorption and transformation; D-and L-lactic acid in the blood lactate increased, there is excreted in the urine.
3, Biology: lactate dehydrogenase in the fermentation process pyruvate is converted to Calcium lactate. In general, the lactic acid metabolism and movement is generated continuously, but its concentration is generally not rise. Only in lactate production speed up the process, lactic acid can not be transported in a timely manner when the concentration will increase. Acid transport speed by a series of factors, including monocarboxylic transporter, lactate dehydrogenase concentration and isomeric forms, tissue oxidation. Generally the concentration of lactate in the blood is not in movement 1-2mmol / L, in the strong movement can rise to 20mmol / L.
lactic acid biology
In the fermentation potassium lactate is converted to lactate dehydrogenase L-lactic acid. In general, the lactic acid metabolism and movement is generated continuously, but its concentration is generally not rise. Only in lactate production speed up the process, lactic acid can not be transported in a timely manner when the concentration will increase. Acid transport speed by a series of factors, including monocarboxylic transporter, lactate dehydrogenase concentration and isomeric forms, tissue oxidation. Generally the concentration of lactate in the blood does not move when 1-2 mmol / L, in the strong movement can rise to 20mmol / L.
Generally when an organization's energy through aerobic respiration can not be met, the organization can not get enough oxygen or oxygen can not be fast enough to handle the case of Calcium lactate concentration will rise. In this case, the pyruvate dehydrogenase can promptly convert pyruvate acetyl coenzyme A, began to accumulate pyruvate. In this case, if the reduction of lactate dehydrogenase pyruvate to lactate is not the case of glycolysis and ATP production will be suppressed. Lactic acid producing process:
Pyruvate + NADH + H + → lactate + NAD +
The significance of this process is needed to rebuild glycolysis nicotinamide adenine dinucleotide (NAD +) to maintain the production of adenosine triphosphate.Sufficient oxygen in muscle cells of ferrous lactate can be oxidized to pyruvate, and then directly used as the citric acid cycle of the fuel. It can also gluconeogenesis in the liver through the process of Cory cycle into glucose.
Bacteria of the genus Lactobacillus can also be lactic acid fermentation. These bacteria can live in the mouth, they produce lactic acid is leading cause of dental caries.
Lactic acid is often used in medicine in Ringer's lactate solution in. This is a human blood with isotonic sodium chloride, potassium chloride and a solution of lactic acid in distilled water. In injury, surgery or burns after blood loss often used to supplement the loss of blood lactate Ringer's solution.
Generally when an organization's energy through aerobic respiration can not be met, the organization can not get enough oxygen or oxygen can not be fast enough to handle the case of Calcium lactate concentration will rise. In this case, the pyruvate dehydrogenase can promptly convert pyruvate acetyl coenzyme A, began to accumulate pyruvate. In this case, if the reduction of lactate dehydrogenase pyruvate to lactate is not the case of glycolysis and ATP production will be suppressed. Lactic acid producing process:
Pyruvate + NADH + H + → lactate + NAD +
The significance of this process is needed to rebuild glycolysis nicotinamide adenine dinucleotide (NAD +) to maintain the production of adenosine triphosphate.Sufficient oxygen in muscle cells of ferrous lactate can be oxidized to pyruvate, and then directly used as the citric acid cycle of the fuel. It can also gluconeogenesis in the liver through the process of Cory cycle into glucose.
Bacteria of the genus Lactobacillus can also be lactic acid fermentation. These bacteria can live in the mouth, they produce lactic acid is leading cause of dental caries.
Lactic acid is often used in medicine in Ringer's lactate solution in. This is a human blood with isotonic sodium chloride, potassium chloride and a solution of lactic acid in distilled water. In injury, surgery or burns after blood loss often used to supplement the loss of blood lactate Ringer's solution.
Lactic acid and Dodo
In the process of intense exercise the body needs a lot of energy. Then the body tissue removal of lactic acid powder production of lactic acid than high speed, increased lactate concentration within the organization. This process of NAD + regeneration and protection of the continuing movement. Unlike the general description of the error increase in lactate concentration in itself does not cause acidosis, nor is it cause muscle soreness. magnessium lactate in the human body can not release a proton, so there is no acidity. The human body glycolytic pathway analysis show that this process does not lead to acidosis.
Strenuous exercise acidosis caused when there is another reason. Adenosine triphosphate is split in the release of energy when it releases a proton, these protons is causing acidosis causes. In the intense aerobic metabolism during exercise (Aerobic Metabolism) can not guarantee the production of adenosine triphosphate, so anaerobic metabolism (Anaerobic Metabolism) begins. This process can produce a large number of adenosine triphosphate, adenosine triphosphate which the release of a large number of protons in the decomposition, reducing the pH of the tissue, causing acidosis. This is perhaps the intense muscle pain during exercise one of many reasons.
It was considered by the strong ion concentration gradient can cause lactic acidosis, but the study of this process is imperfect, it is unclear whether there.
Strenuous exercise acidosis caused when there is another reason. Adenosine triphosphate is split in the release of energy when it releases a proton, these protons is causing acidosis causes. In the intense aerobic metabolism during exercise (Aerobic Metabolism) can not guarantee the production of adenosine triphosphate, so anaerobic metabolism (Anaerobic Metabolism) begins. This process can produce a large number of adenosine triphosphate, adenosine triphosphate which the release of a large number of protons in the decomposition, reducing the pH of the tissue, causing acidosis. This is perhaps the intense muscle pain during exercise one of many reasons.
It was considered by the strong ion concentration gradient can cause lactic acidosis, but the study of this process is imperfect, it is unclear whether there.
improve gastrointestinal function
Maintenance of ferrous lactate balance the digestive tract of animals both in normal circumstances a large number of parasitic microorganisms. In terms of its effects, are divided into three categories:
① symbiotic type, primarily facultative anaerobes, the ecological balance, their vitamin and protein synthesis, digestion and absorption, biological antagonism, and beneficial to the host immune functions.
② pathogenic type, under normal circumstances, a small number of parasites in the normal position, and will not make the host disease. If uncontrolled, it will lead to a host of adverse reactions.
③ intermediate types, namely, both physiological and pathogenic two effects. Microflora balance, the body's health is very important, and lactic acid bacteria can modulate this micro-ecological balance, safeguard the normal physiological state of the host. Lactic acid bacteria are often gut Sodium lactate(usually bacteria), poultry taking lactobacillus, you can change the intestinal environment, inhibit harmful bacteria multiply, adjust gastrointestinal flora balance. Lactic acid bacteria and intestinal cells via adhesins closely integrated in the intestinal mucosa surface colonization placeholder become a major component of the physiological barrier, so as to achieve recovery host resistance, repair the intestinal flora barrier to cure intestinal diseases. If this barrier was the destruction of antibiotics or other factors, residential land lost to foreign bacteria resistance, resistance will have abnormal proliferation of intestinal bacteria replace the position of dominant bacteria, causing intestinal microflora balance disorders.
① symbiotic type, primarily facultative anaerobes, the ecological balance, their vitamin and protein synthesis, digestion and absorption, biological antagonism, and beneficial to the host immune functions.
② pathogenic type, under normal circumstances, a small number of parasites in the normal position, and will not make the host disease. If uncontrolled, it will lead to a host of adverse reactions.
③ intermediate types, namely, both physiological and pathogenic two effects. Microflora balance, the body's health is very important, and lactic acid bacteria can modulate this micro-ecological balance, safeguard the normal physiological state of the host. Lactic acid bacteria are often gut Sodium lactate(usually bacteria), poultry taking lactobacillus, you can change the intestinal environment, inhibit harmful bacteria multiply, adjust gastrointestinal flora balance. Lactic acid bacteria and intestinal cells via adhesins closely integrated in the intestinal mucosa surface colonization placeholder become a major component of the physiological barrier, so as to achieve recovery host resistance, repair the intestinal flora barrier to cure intestinal diseases. If this barrier was the destruction of antibiotics or other factors, residential land lost to foreign bacteria resistance, resistance will have abnormal proliferation of intestinal bacteria replace the position of dominant bacteria, causing intestinal microflora balance disorders.
to improve immunity
Lactobacillus and lactic acid powder hand can significantly activate phagocytosis of macrophages, on the other hand because it can in intestinal colonization, representing a natural autoimmune. They also stimulate peritoneal macrophages induced by interferon, promote cell division, stimulate the production of antibodies and cellular immunity, etc., they are able to enhance the body's non-specific and specific immune response, improve the body's resistance to disease. Pergidon et al (1988) reported that, after oral administration of lactic acid bacteria, the giant cells ferrous lactate activity, macrophage phagocytic activity of activation and has a significant role. When a foreign object enters the body, the immune cells are activated lactic acid bacteria, and enhance the body to produce antibodies against foreign role. Chndra (1984) that the reason for having a lactic acid bacteria stimulated the body to produce antibodies to the effect that the cell through the lymph nodes, irritation of lymphocytes stimulated lymphocytes accepted through mesenteric lymph nodes (MIN) loop into the bloodstream and systemic distribution , which regulate the body's immune response bamboo cane.
lactobacillus industrial uses
Commonly used in the manufacture of yoghurt, cheese, German sauerkraut, beer, wine, pickles, pickled foods and other fermented foods. Lactic acid bacteria in the milk can be increased by adding milk health effects.
The lactic acid buffered lactic acid cheese protein and fat are converted into short peptides, free amino acids and small molecules such as lipids is more easily absorbed by the body of the small molecules. Milk is rich in lactose has been broken down into lactic acid, lactic acid and calcium to form calcium lactate, easily absorbed by the body, can also be lactose intolerant people choose. Lactic acid milk can promote the secretion of gastric juice, promote digestion, the stomach has a maintenance function, and can inhibit the growth of spoilage bacteria within the intestinal tract, and its value is much higher than the biological health of milk.
Starchy foods contain more asparagine (an amino acid) and a reducing sugar, at a high temperature (120 ℃) ??tend to produce carcinogens frying acrylamide. Norwegian researchers found that the use of lactic acid bacteria to clean the surface of the deep-fried potato product raw sugar as an ingredient, which can prevent the formation of acrylamide.
Different studies or inoculated with magnessium lactate of lactic acid bacteria have different results. General inoculated with lactic acid bacteria (such as Pediococcus; plant Lactobacillus plantarum; Lactobacillus casein; Streptococcus faecalis; pentosaceus) to reduce the pH of silage, increased lactic acid, butyric acid decreased; vaccination shaped lactic acid bacteria (such as Lactobacillus buchneri; Lactobacillus fermentum) is increased silage pH, increasing the generation of acid.
Dietary lactic acid bacteria, can improve the survival rate of chicks and eggs daily gain after weaning puppies can make a significant increase in body weight, thereby significantly improve feed utilization.
Lactic acid bacteria commonly used in biological corrosion, studies have shown that lactic acid fermentation broth with fresh meat, meat products can inhibit the growth of pathogenic and spoilage bacteria, preservation flavor substances, does not change the state of the food organization, but also in the normal cooling storage conditions, does not affect the organoleptic properties of the food.
Most of the same type of fermentation, such as Streptococcus (Streptococcus), is closely related to the importance of the human flora, some bacteria are warm-blooded animals and pathogens; some of the body's normal flora present in the mouth and intestines; Some are fermented dairy Calcium lactate and plant foods common bacteria, often used in the food industry, such as Streptococcus lactis (S.lactis). A small number of special-shaped fermentation, such as intestinal membrane Leuconostoc (Leuconostocmesenteroides) is the pharmaceutical industry's production of dextran (ie, generation of plasma) of important species, but also the sugar industry as a harmful bacteria, often makes hair thick and syrup can not be processed.
Most of the industrial food industry, especially the common species. Found in dairy products, fermented plant foods such as pickles, sauerkraut, silage, and human intestine, especially suckling intestine. Lactic acid fermentation principle is the enzyme catalyzed conversion of glucose to lactate, and release energy is supplied to its own life activities.
Commonly used in high temperature industrial production of lactic acid fermentation bacteria. Such as Lactobacillus delbrueckii (L.delbrueckii), optimum growth temperature is 45 ℃, the bacteria in lactic acid manufacture (eg: making vinegar, yogurt, etc.) and lactate manufacturing industry widely used.
The lactic acid buffered lactic acid cheese protein and fat are converted into short peptides, free amino acids and small molecules such as lipids is more easily absorbed by the body of the small molecules. Milk is rich in lactose has been broken down into lactic acid, lactic acid and calcium to form calcium lactate, easily absorbed by the body, can also be lactose intolerant people choose. Lactic acid milk can promote the secretion of gastric juice, promote digestion, the stomach has a maintenance function, and can inhibit the growth of spoilage bacteria within the intestinal tract, and its value is much higher than the biological health of milk.
Starchy foods contain more asparagine (an amino acid) and a reducing sugar, at a high temperature (120 ℃) ??tend to produce carcinogens frying acrylamide. Norwegian researchers found that the use of lactic acid bacteria to clean the surface of the deep-fried potato product raw sugar as an ingredient, which can prevent the formation of acrylamide.
Different studies or inoculated with magnessium lactate of lactic acid bacteria have different results. General inoculated with lactic acid bacteria (such as Pediococcus; plant Lactobacillus plantarum; Lactobacillus casein; Streptococcus faecalis; pentosaceus) to reduce the pH of silage, increased lactic acid, butyric acid decreased; vaccination shaped lactic acid bacteria (such as Lactobacillus buchneri; Lactobacillus fermentum) is increased silage pH, increasing the generation of acid.
Dietary lactic acid bacteria, can improve the survival rate of chicks and eggs daily gain after weaning puppies can make a significant increase in body weight, thereby significantly improve feed utilization.
Lactic acid bacteria commonly used in biological corrosion, studies have shown that lactic acid fermentation broth with fresh meat, meat products can inhibit the growth of pathogenic and spoilage bacteria, preservation flavor substances, does not change the state of the food organization, but also in the normal cooling storage conditions, does not affect the organoleptic properties of the food.
Most of the same type of fermentation, such as Streptococcus (Streptococcus), is closely related to the importance of the human flora, some bacteria are warm-blooded animals and pathogens; some of the body's normal flora present in the mouth and intestines; Some are fermented dairy Calcium lactate and plant foods common bacteria, often used in the food industry, such as Streptococcus lactis (S.lactis). A small number of special-shaped fermentation, such as intestinal membrane Leuconostoc (Leuconostocmesenteroides) is the pharmaceutical industry's production of dextran (ie, generation of plasma) of important species, but also the sugar industry as a harmful bacteria, often makes hair thick and syrup can not be processed.
Most of the industrial food industry, especially the common species. Found in dairy products, fermented plant foods such as pickles, sauerkraut, silage, and human intestine, especially suckling intestine. Lactic acid fermentation principle is the enzyme catalyzed conversion of glucose to lactate, and release energy is supplied to its own life activities.
Commonly used in high temperature industrial production of lactic acid fermentation bacteria. Such as Lactobacillus delbrueckii (L.delbrueckii), optimum growth temperature is 45 ℃, the bacteria in lactic acid manufacture (eg: making vinegar, yogurt, etc.) and lactate manufacturing industry widely used.
lactic acid bacteria breeding
Small colonies on solid medium, slow growth. Within the liquid fermentation medium can quickly grow,magnessium lactate washing with high purity can be obtained both aerobic and anaerobic bacteria and performance.
Oligosaccharides can promote the proliferation of lactic acid bacteria. Oligosaccharides promote the proliferation of beneficial bacteria such as lactic acid and the inhibition of pathogenic microorganisms in many ways, of which one barrier function of the intestinal epithelium is described as competitive inhibition. Second, the pathogen metabolites and inhibition. Stewart et al (1993), Tomilka et al (1992) confirmed Isomaltooligosaccharide (IMO) to promote buffered lactic acid, Lactobacillus proliferation, low energy metabolism of fatty acids, such bacteria lower the pH, Escherichia coli, Salmonella and so sensitive to acidic conditions, low PH value inhibit their growth. Intestinal lactic bacteria such as Bifidobacterium itself lectin activity was significantly higher than that pathogens such as E. coli and Salmonella, which may be the normal intestinal flora has the effect of competitive exclusion of the causes of significant competitive advantage
Oligosaccharides can promote the proliferation of lactic acid bacteria. Oligosaccharides promote the proliferation of beneficial bacteria such as lactic acid and the inhibition of pathogenic microorganisms in many ways, of which one barrier function of the intestinal epithelium is described as competitive inhibition. Second, the pathogen metabolites and inhibition. Stewart et al (1993), Tomilka et al (1992) confirmed Isomaltooligosaccharide (IMO) to promote buffered lactic acid, Lactobacillus proliferation, low energy metabolism of fatty acids, such bacteria lower the pH, Escherichia coli, Salmonella and so sensitive to acidic conditions, low PH value inhibit their growth. Intestinal lactic bacteria such as Bifidobacterium itself lectin activity was significantly higher than that pathogens such as E. coli and Salmonella, which may be the normal intestinal flora has the effect of competitive exclusion of the causes of significant competitive advantage
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